DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and TBC1D9

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_055945.2	Gene:	TBC1D9 / 23158	HGNCID:	21710	Length:	1266	Species:	Homo sapiens

Alignment Length:	649	Identity:	161/649 - (24%)
Similarity:	259/649 - (39%)	Gaps:	158/649 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 PEQSSNKLLSIPFVEDAQQRLQWIAHL-EFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHT 168
            ||:.:.||......|.|     |..|. |:...            :.:.||||.|.:|.:|||.:
Human   472 PEEFNPKLAKEFLKEQA-----WKIHFAEYGQG------------ICMYRTEKTRELVLKGIPES 519

  Fly   169 LRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPR 233
            :|.::|:.||||:.:|......|.|:|:.|.....:.:::||:||.|.||.:..|.|.  .||..
Human   520 MRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNE--MGIAA 582

  Fly   234 LRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQ 298
            |||:|...|:..|:|||||...::.:.|||:.:||.|||::..:.|.:|| .||::.::|...||
Human   583 LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQ 646

  Fly   299 RVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLT 363
            .|...|..:|:..:.:.::...: :|.|:|.||||||.:|:..:..|.:.|.|||||..|:|||.
Human   647 GVFEELARDYVPQLYDCMQDLGV-ISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLA 710

  Fly   364 LGMLKVKEQDLKHLENSAQIFNSLSDIPGEVT------------------DVE------------ 398
            |.:|......|.:.::..:....|......||                  |||
Human   711 LAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIR 775

  Fly   399 ----------------VLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQI------------ 435
                            :.|:|.|:|    .||:.||.:|..:..::.:....|
Human   776 TSYEKFGTIRADLIEQMRFKQRLKV----IQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKA 836

  Fly   436 ---------GNPEAA----PNLPKQQLARRQVRKSKSILEAFLFR-GDGNEGD-------QLKNK 479
                     |:..|.    |:||..:..|....:.|.:. |.||. ..|...|       ||.::
Human   837 EHLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMF-ALLFPWACGTHSDVLASRLFQLLDE 900

  Fly   480 NIRQTEILVDLREAI--LKVGRH-FITIEPKLAGHIQLTANYSTESHAKDH-----ENFINVART 536
            |   .:.|::.||.:  |....| .:|.:.||...:.:....|::....|.     :.|......
Human   901 N---GDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDITP 962

  Fly   537 RKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGE-------LNGLRGWFP-------- 586
            .......|....:...|: ||     :|:..:.|:    |:       .|.||.|.|
Human   963 ECTHVVGLDSRSKQGADD-GF-----VTVSLKPDK----GKRANSQENRNYLRLWTPENKSKSKN 1017

  Fly   587 ---------AKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGP 641
                     .:|:||.   ..:|....:|...:   :|...| |......||.|.....|:..|
Human  1018 AKDLPKLNQGQFIELC---KTMYNMFSEDPNEQ---ELYHAT-AAVTSLLLEIGEVGKLFVAQP 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	79/213 (37%)
		SH3_SGSM3	540..592	CDD:212747	13/75 (17%)
		RUN	619..773	CDD:280855	7/23 (30%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..456
		TBC	512..722	CDD:214540	79/213 (37%)
		EFh	<893..923	CDD:385324	8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1095		161/649 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840