DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12241 and TBC1D9B

DIOPT Version :9

Sequence 1:NP_650432.1 Gene:CG12241 / 41834 FlyBaseID:FBgn0038304 Length:804 Species:Drosophila melanogaster
Sequence 2:NP_942568.2 Gene:TBC1D9B / 23061 HGNCID:29097 Length:1250 Species:Homo sapiens


Alignment Length:753 Identity:169/753 - (22%)
Similarity:291/753 - (38%) Gaps:191/753 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 VADGLRPNPG---GPFSALTASM---------WPQEILAKLGGGAELASGPNDQPEYRFDEFGFR 98
            ::|.|:..|.   |...:..||:         .|||       |:|..:.|......|   ..|.
Human   390 ISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQE-------GSEQPASPASPLSSR---QSFC 444

  Fly    99 VEEEDGPEQSSNKLL--SIPFVED-----AQQRLQ---WIAHLEFSHNKEAAELSWEHVDVMLPR 153
            .:|.....|...||.  :.| :||     |:::::   |..|. |.:.:          .|.:.|
Human   445 AQEAPTASQGLLKLFQKNSP-MEDLGAKGAKEKMKEESWHIHF-FEYGR----------GVCMYR 497

  Fly   154 TEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILP 218
            |.|.|.:|.:|||.:||.::|:..|||..:.......|.::|:.|:....:.:::||:||.|.:|
Human   498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMP 562

  Fly   219 TNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLP 283
            .:..|.|.  .||..|||:|...|:..|.|||||...::.:.|||:..||.|||::..:.|.:||
Human   563 EHPAFQNE--LGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLP 625

  Fly   284 ASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIW 348
             .||::.::|...||.:...|..::|..:.|.::...: :|.|:|.||||||.:|:..:..|.|.
Human   626 -DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISLSWFLTLFLSVMPFESAVVIV 688

  Fly   349 DWFFYEGSIVLFQLTLGMLKVKEQDL--------------KHLENSAQ-------------IFNS 386
            |.|||||..|:.|:.|.:|....:.|              ::|:|...             :.:|
Human   689 DCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSS 753

  Fly   387 LSDIPGEVTDVEVL-------------------FRQALEVGGSLSQTVIDTHRRRHLAYLMADQG 432
            ..|.|.||...|:|                   |:|.|:|    .|::.||.:|..:..:..|.|
Human   754 SDDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKV----IQSLEDTAKRSVVRAIPVDIG 814

  Fly   433 HQIGNPE-------------------------AAPNLPKQQLARRQVRKSKSILEAFLFRGDGNE 472
            ..|...|                         ..|:||..:..|....:.:.:..:......|:.
Human   815 FSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSH 879

  Fly   473 GDQLKNKNIR----QTEILVDLREAILKVGRHF---ITIEPKLAGHIQLTANYSTESHAKDHENF 530
            ...|..:..|    ..:.|::.:|.:..:...:   :|.:.|:...:.|....|.|.        
Human   880 TPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEE-------- 936

  Fly   531 INVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDE 595
                  .:...:|.|.|......|.....:|:...:                   |.:..|.|.:
Human   937 ------AESALEAAHYFTEDSSSEASPLASDLDLFL-------------------PWEAQEALPQ 976

  Fly   596 RSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEAATREVEKDF 660
            ..:  ..:|.:...|.     :||.:|..:.:|....|               |:.|.:|..||.
Human   977 EEQ--EGSGSEERGEE-----KGTSSPDYRHYLRMWAK---------------EKEAQKETIKDL 1019

  Fly   661 ESVYSR--LVLCKT-YRLDEDGKVLTPEELLYRCVQAI 695
            ..:...  :.|||| |.:..:..:   |:.||..:..:
Human  1020 PKMNQEQFIELCKTLYNMFSEDPM---EQDLYHAIATV 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12241NP_650432.1 TBC 161..375 CDD:214540 76/227 (33%)
SH3_SGSM3 540..592 CDD:212747 6/51 (12%)
RUN 619..773 CDD:280855 17/80 (21%)
TBC1D9BNP_942568.2 PH-GRAM1_TCB1D9_TCB1D9B 153..251 CDD:275420
PH-GRAM2_TCB1D9_TCB1D9B 299..394 CDD:270161 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..443 11/55 (20%)
TBC 505..715 CDD:214540 75/213 (35%)
EFh <855..906 CDD:298682 6/50 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..999 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1069..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1157
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R540
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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