DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc-19

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_510336.3	Gene:	tbc-19 / 181511	WormBaseID:	WBGene00007849	Length:	1333	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	98/355 - (27%)
Similarity:	155/355 - (43%)	Gaps:	79/355 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIA----HLEFSHNKEAAE--LSW------- 144
            |.||||:..::.|                 ..|.::|    |...:.:|.|:|  .:|
Worm   388 DSFGFRISFKEEP-----------------NALHYMATKLNHFYANRSKSASEHKYNWKRFLEEN 435

  Fly   145 EHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKS------------------ETSY 191
            :.:|:    |.:.:.|.|:|||::|||.:|..|.....:..|:                  |.:|
Worm   436 DFIDL----TPETKIMCRKGIPNSLRATVWKILINQQVEDLKNVYGKYYYRNLCNIQGGEDEKTY 496

  Fly   192 HDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGV 256
            .|:          ..|||..||||.:|.|..|.:.|..|:.:|.::|.........||||||...
Worm   497 SDV----------HQKQINLDLLRTMPNNVHFMSANSKGVTQLLQVLHAFCLHNSQIGYCQGMNF 551

  Fly   257 IVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDI 321
            :.|..|||:..|:|||.:..:.|.....:|:.|.|.|.||||.|:..|:......:.:.|:..||
Worm   552 LAATALLFVGPEDAFWFLIAVTERYFDKTYFDSNLTGAQADQEVLKGLLEVQHPKIMKHLKSLDI 616

  Fly   322 ELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQL-----------------TLGMLKV 369
            :::..||:||::||.:.|....|:||||.|..||..|||:.                 .:|:::|
Worm   617 DVASFTLNWFISLFFDAVPFNTLLRIWDCFLLEGPKVLFRFAIVLIGKHEEEIISRGDAIGIMRV 681

  Fly   370 KEQDLKHLENSAQIFNSLSDIPGEVTDVEV 399
            .:...|...:...|.|....||...|.:|:
Worm   682 SKAATKLAFDEEAIVNMAFRIPNLPTRIEL 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	75/248 (30%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc-19	NP_510336.3	PH-like	13..112	CDD:302622
		PH	16..110	CDD:278594
		TBC	448..670	CDD:214540	73/231 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820