DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and tbc-18

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_509421.2	Gene:	tbc-18 / 181091	WormBaseID:	WBGene00018281	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	803	Identity:	353/803 - (43%)
Similarity:	519/803 - (64%)	Gaps:	78/803 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEED-----GPEQ--SSNKL 112
            |.||||:..:|.|..|               :.|...|||||||.:::|     |.|:  ||.|.
Worm    49 GKPFSAINKAMLPIYI---------------EDPLEFFDEFGFRKQDDDHDPNLGDEEETSSAKH 98

  Fly   113 LSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQ-GIPHTLRAQMWMR 176
            ||.| :|::..:|:.|::|:..|.:...::.|.|:.....:|::...:::: ||||::|..:|.|
Worm    99 LSEP-LENSTHKLKLISYLQDVHKEVKDDVLWSHILGPELKTDRFEELLKEGGIPHSMRPFLWPR 162

  Fly   177 LSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGI 241
            ||||..|::.::.:|..:::..:.|:.....|||:||||.||.|.||...|..||..|||||:.:
Worm   163 LSGATKKQKDAKYTYESVLQQCAQDKPSIGVQIERDLLRTLPNNICFWKKNSEGIEALRRILKCV 227

  Fly   242 AWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIA 306
            |:::||:|||||.|||||.|||:..||..||||..::||:||.::|:.||||:|||:||...|:.
Worm   228 AFIYPDLGYCQGMGVIVATLLLYCSEETTFWMMTALIEDILPPNFYTQTLLGLQADERVSRHLMK 292

  Fly   307 NYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKE 371
            .::..::::|..:::|:||:|:.|.||||.:|...::::|:||:.||.|.:.:|::.:.:||:||
Worm   293 CHVPDLNKALEDYEVEVSLLTVSWLLTLFGSVFRTRVMLRVWDFIFYSGGVNIFRVIISILKMKE 357

  Fly   372 QDLKHL----ENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTH-----RRRHLAYL 427
            |::..:    ::||.||.:||.:|..||:||    :.:|..||...|:.| |     |::|.|.|
Worm   358 QEIVEIAETTQSSADIFTALSQLPASVTEVE----KVIEYMGSFEFTITD-HLIAELRKKHQAVL 417

  Fly   428 MADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLRE 492
            ||||| .|.|.....|||||...||::.:||||::......|....|. |:||||||||||||:|
Worm   418 MADQG-MIVNTATDTNLPKQTTQRRKLTRSKSIIKQIFSSKDETANDP-KSKNIRQTEILVDLKE 480

  Fly   493 AILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGF 557
            ::|::.|:||:.:.|:..::...|:||.|||.||..|::...|...:||:||.||.|.:::||||
Worm   481 SVLQICRYFISCDEKMELNVCTQADYSPESHNKDIANYLKGRRVGAKRARALLDFAREEENELGF 545

  Fly   558 RRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAP 622
            |:|||:||||:|||||||||:|||||||||||||::|||.|.||..||:|:|..:|:.:||.||.
Worm   546 RKNDIVTIISEKDEHCWVGEVNGLRGWFPAKFVEVVDERGKSYTIYGDEAVSPEITEYIRGRLAN 610

  Fly   623 AIKAFLEHGMK-RPTFLGGPIHPWLYIEEAATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEE 686
            :.:..::||:: ...:.....|||.:||:.|...|||:|.||||||.||.|:.||||||:|||||
Worm   611 SFRQIMDHGIRENALYTSMAYHPWSFIEDIAYYSVEKNFNSVYSRLTLCNTFNLDEDGKILTPEE 675

  Fly   687 LLYRCVQAINQTHDDAHAQMDVKLRSLICLGLNEQVLHLWLEVLCAC---QEVVQKWYHSWSFID 748
            ||:|.||.||.:|:...|..|||||||:.:|:|||.:|||.::||:.   :.:..|:||||:||.
Worm   676 LLFRSVQLINDSHNAVSAHSDVKLRSLLVVGVNEQCIHLWFDLLCSATQHEHIRNKYYHSWAFIR 740

  Fly   749 SPGWVQIKCELRILSQFAFNLNPDWELP--------------------------------PKRGK 781
            ||.|.||||:||:||||:|||:..:|:.                                .:.|:
Worm   741 SPAWRQIKCDLRLLSQFSFNLSMSFEIEGIDKKKRKFVNGLLTSQKKKILSTVVSSSQDNKQNGE 805

  Fly   782 ESQPLKDGVRDMLVKHHLFSWDL 804
            |  |||.||.|||:|||||||||
Worm   806 E--PLKQGVTDMLIKHHLFSWDL 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	94/214 (44%)
		SH3_SGSM3	540..592	CDD:212747	40/51 (78%)
		RUN	619..773	CDD:280855	82/157 (52%)
tbc-18	NP_509421.2	TBC	148..361	CDD:214540	94/212 (44%)
		SH3_SGSM3	528..580	CDD:212747	40/51 (78%)
		RUN	607..765	CDD:280855	82/157 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157338
Domainoid	1	1.000	209	1.000	Domainoid score	I1663
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9249
Inparanoid	1	1.050	669	1.000	Inparanoid score	I384
Isobase	1	0.950	-	0	Normalized mean entropy	S1881
OMA	1	1.010	-	-		QHG48054
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	1	1.000	-	-		FOG0007050
OrthoInspector	1	1.000	-	-		oto19981
orthoMCL	1	0.900	-	-		OOG6_107028
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X5135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790