DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc-16

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_508988.3	Gene:	tbc-16 / 180856	WormBaseID:	WBGene00018639	Length:	725	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	76/347 - (21%)
Similarity:	138/347 - (39%)	Gaps:	72/347 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 GPNDQPEYRFDEFG---FRVEEEDGPEQSSNKLLSI--PFV----EDAQQRL-------QWIAHL 131
            |..|:..|.|:::.   .|..:|..|...::|.|.|  |.|    :|.::.|       .|.::
Worm   327 GGLDKLAYIFEQWSSIKARSVQEGSPSAIADKQLIICQPAVTKVEKDPEEGLFEKITLNTWRSY- 390

  Fly   132 EFSHNKEAA---------ELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKS 187
               .||...         .:.:..:||      ::|..|   .|..||...| ..|....:..|:
Worm   391 ---ENKSGVIIDSGTVRKHIFFASMDV------EMREKV---WPFLLRVYPW-ESSADQRENIKN 442

  Fly   188 E--TSYHDIVK----ASSNDQ---LMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAW 243
            :  ..|.:|.|    .:.|.|   :.....|.||::|....|..|:..|......::.||...|.
Worm   443 DLFLEYQNIRKRRYRVTENAQARWISIENSIVKDVVRTDRKNPFFAGDNNPNSEIMKNILLNYAV 507

  Fly   244 LFPDIGYCQGTGVIVACLLLFMEEE-NAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHT---- 303
            ::|||.|.||...::|.||..:::| ::::..    ::.:..:.:|||   .|.::.:|.|
Worm   508 MYPDINYIQGMSDLLAPLLSTLKDEVDSYFCF----KNFMQQTVFSST---PQGNENLMETNLTY 565

  Fly   304 ---LIANYLSSVDESLRKHDIE-LSLITLH-WFLTLFANVVHMKILVRIWD--WFFYEGSIVLFQ 361
               ::..::....|.|.|...: :.|:.:| |.|..|.........:.||:  |..|..:.....
Worm   566 LRNMLRMFVPDFYEHLEKQRPDAMQLMFVHRWILLCFKREFPENYALHIWECCWAHYRTNYFHLF 630

  Fly   362 LTLGMLK-----VKEQDLKHLE 378
            :.:.::.     |..|||.|.|
Worm   631 VCVAIVSIYGKDVLTQDLPHDE 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	53/239 (22%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc-16	NP_508988.3	DUF3548	32..>136	CDD:371881
tbc-16	NP_508988.3	TBC	415..644	CDD:214540	51/239 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810