Protein Alignment CG12241 and tbc-11

DIOPT Version :9

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_508178.2
• Gene: tbc-11 / 180444
• WormBaseID: WBGene00018075
• Length: 934
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 134/590 - (22%)
• Similarity: 217/590 - (36%)
• Gaps: 141/590 - (23%)

  Fly    80 LASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSW 144
            |...|:..|.......|....:.|.|..|.:..:|....|:         |||.          |
 Worm   353 LGKSPSRMPTQLLHPTGDDESDCDEPLLSGSGKVSQECKEE---------HLEM----------W 398

  Fly   145 ----EHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGA--LAKKQKS-ETSYHDIVKASSNDQ 202
                |:.|....|.:|:..:|..|||..||.::|..||..  ||..|.. ...||..:     .|
 Worm   399 DQLIENWDQQSDRPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFL-----SQ 458

  Fly   203 LMTSKQ-IEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFME 266
            ...|:| |.:|:.|..|.:..|....|.|...|.:|.:..:....::.||||...:.|.|||.|.
 Worm   459 PCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMP 523

  Fly   267 EENAFWMMATI-----VEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLI 326
            ||.||..:..|     :.||....:.:..|...|     :..|:.:|:..:...|....||..:.
 Worm   524 EEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQ-----LTALLKDYIPDLSHHLEHIGIETHMY 583

  Fly   327 TLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIP 391
            ...||||||.....::::..|.|.|..:|...:|.::|.:|...:.||..|:....:......:|
 Worm   584 ASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEGTLKYFRVSLP 648

  Fly   392 GEV-TDVE--------VLFR---QALEVGGSLSQTVIDTHRRRHLAYLMADQ---GHQIG----- 436
            .:. |:..        |.||   ..|||..:..:.:.:..|......|..::   .||..
 Worm   649 RKYRTEASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERENEDPVLRMEKEIGRHQANTLRLE 713

  Fly   437 --NPEAAPNL--PKQQLAR-----------------RQVRKSKSILEAFLFRGDGNEGDQLKNKN 480
              |.:.|..|  .|.:|.|                 |..|::..|||              :|||
 Worm   714 RENDDLAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQNMDILE--------------ENKN 764

  Fly   481 I-RQTEILVDL-REAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKA 543
            : |:.|.:.:: |..:|::..:....|..||.:.:|.:.                   |.:||:
 Worm   765 LMREYEQIKEMYRRDVLRLEENGSRAEKLLAEYKKLFSE-------------------RSKRAE- 809

  Fly   544 LHDFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKLY---TSAGD 605
                  ::.:....::..||..||..|: ||           || ..|....||.::   |..|.
 Worm   810 ------NEREHFEVQKKAIIARISDCDK-CW-----------PA-VCEWEKNRSPVHSASTPTGP 855

  Fly   606 DAISE 610
            |.:::
 Worm   856 DLLTK 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	63/222 (28%)
		SH3_SGSM3	540..592	CDD:212747	11/51 (22%)
		RUN	619..773	CDD:280855
tbc-11	NP_508178.2	PH-like	11..147	CDD:388408
		DUF3694	183..293	CDD:372133
		TBC	419..632	CDD:214540	63/222 (28%)
		Smc	<697..>901	CDD:224117	42/217 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910