Protein Alignment CG12241 and tbc-9

DIOPT Version :9

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_502598.2
• Gene: tbc-9 / 178316
• WormBaseID: WBGene00012868
• Length: 1247
• Species: Caenorhabditis elegans
• Alignment Length: 631
• Identity: 167/631 - (26%)
• Similarity: 252/631 - (39%)
• Gaps: 169/631 - (26%)

  Fly    98 RVEEEDGPEQSS------NKLL-------SIPFVEDAQQ--RLQWIAHLEFSHNKEAAELSWEHV 147
            :.:.|.|...:|      :||:       ..||..||..  |.:|        ||...|..   .
 Worm   419 KADSERGRSSTSSSSSSFDKLIWDCPLIEKYPFGADASDKCREKW--------NKYLQEYG---T 472

  Fly   148 DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKD 212
            .|.:.||.:|..::.:|:|..||.|:||..|||.|:...:...|.:::..:.....:..::||:|
 Worm   473 GVCMYRTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELLHKNQGVYSVALEEIERD 537

  Fly   213 LLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATI 277
            |.|.||.:..|.  .|.||..|||||...|:..|:|||||...::.:.||||.:||.|||::..:
 Worm   538 LHRSLPEHPAFQ--QGPGIDALRRILTAYAFRNPNIGYCQAMNIVGSVLLLFTKEEEAFWLLVAV 600

  Fly   278 VEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMK 342
            .|.||| .||::.::|...||.|...|:...|.:|...|.:..:: .::.|.||||:|.:.:...
 Worm   601 CERLLP-DYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFD 663

  Fly   343 ILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEV 407
            ..|||.|.||:||:.::||:.|.|||         ||...|..|..|  ||:......:.:::..
 Worm   664 AAVRILDLFFFEGARLMFQVALEMLK---------ENEKLICESRDD--GEILMSLAKYTESIYE 717

  Fly   408 GGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNE 472
            |    .||::                                     ||..::
 Worm   718 G----DTVVE-------------------------------------RKPSTV------------ 729

  Fly   473 GDQLKNKNIRQTEILVDLREA----ILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINV 533
              ||      .|.||.||.||    |..:|.......||:.....|..:|....:...:|| |..
 Worm   730 --QL------GTTILSDLEEAASTMINFMGTDITRTFPKIPIGDLLANSYQNFGYCFTNEN-IET 785

  Fly   534 ARTRKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSK 598
            .|. |.|.|.:.:.|   |:::    ..||..|. ||......||..|  :...|...||..|.:
 Worm   786 LRL-KNRLKVVQNLE---DNQM----RSIIKSIG-KDCRFTNEELEAL--YNVVKEEHLLSWRHR 839

  Fly   599 LYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEAATREVEKD---F 660
            |..||             ||.:|...:      ..||             :..|..:...|   |
 Worm   840 LGVSA-------------RGKMAAVTE------RPRP-------------DPCAQSQYRLDYDLF 872

  Fly   661 ESVYSRLV--------LCKTYRLDE--DGKVLTPEELLYRCVQAIN 696
            ..|:.||:        :.:.:||.:  |..:||..:|      |||
 Worm   873 SEVFPRLLPWPVTNIFIIRVFRLLDISDNGLLTFRDL------AIN 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	78/213 (37%)
		SH3_SGSM3	540..592	CDD:212747	13/51 (25%)
		RUN	619..773	CDD:280855	18/91 (20%)
tbc-9	NP_502598.2	PH-GRAM1_TCB1D9_TCB1D9B	154..253	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	309..406	CDD:270161
		TBC	489..695	CDD:214540	80/218 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940