DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc-2

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_495156.1	Gene:	tbc-2 / 173986	WormBaseID:	WBGene00022880	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	122/485 - (25%)
Similarity:	207/485 - (42%)	Gaps:	88/485 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEHTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQE-------------- 69
            ||.|||:.:..:..|:|||..::|.....:...........|:|.|:..:|
Worm   440 EEATRKVLDEENVRDIGELQDLVEGYRTQNQFLNAEIVQLHAITQSLEDREKKLIRQNFDLEACY 504

  Fly    70 ---------------------------ILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQ 107
                                       :|.:|  ..|.|..|.:..:...|:.||  .::|...:
Worm   505 YQLKSRYLMVLNHFKSPTKPGKIMEPGVLKEL--LEESARTPRESQQNLTDQLGF--YKKDDFSE 565

  Fly   108 SSNKLLSIPF-------------VEDAQQRLQWIAHLEFSHNKEAAELSWEHV--------DVML 151
            |.:.|.:..|             :|.:::.::|:.             ||:..        ...:
Worm   566 SDDLLDTATFYMKKAGDVVEATKLEQSEEYMKWLQ-------------SWDAFLVNNTVSRQTAI 617

  Fly   152 PRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETS---YHDIVKASSNDQLMTS-----KQ 208
            ..:..|:.::|.|:|...|.::|..:.....|.:::|..   |..:::.:...:...|     ||
Worm   618 MSSPDLKTLIRTGVPPAYRGRVWKIIVTHWVKDKQAELGNGYYQSMLRKAGTKKQDGSYDAAIKQ 682

  Fly   209 IEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWM 273
            |:.||.|.||||..|..|:...|.:||.:|....:....:|||||...:.|..||.::|:::||.
Worm   683 IDLDLARTLPTNKLFDEPDSANIEKLRNVLYAFRYHNSHVGYCQGLNRLAAIALLNLDEQDSFWF 747

  Fly   274 MATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANV 338
            :...||.|.|..||:|:|:|..|||:|:..|:|..|..:...||..:::|||..|.||||.|.:|
Worm   748 LVACVEHLQPEGYYTSSLIGAVADQKVLRDLVAEKLPKLAAHLRALEVDLSLFALSWFLTCFVDV 812

  Fly   339 VHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQ 403
            :...|.:.|:|.|.|||:.|||:..|.:.|:.|..:...:....:...||.....:.|.:.|.:.
Worm   813 LPHSIYLTIFDAFLYEGNKVLFRFALALFKICEPHVLQCKTIGTVHQCLSKAQEHIIDFKSLAQV 877

  Fly   404 ALEVGGSLSQTVIDTHRRRHLAYLMADQGH 433
            |........|..|:|.|:.:|..| .|.||
Worm   878 AFNELNPFPQKTIETKRQLYLTQL-KDTGH 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	77/221 (35%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc-2	NP_495156.1	PH_TBC1D2A	20..119	CDD:269966
		PH	20..111	CDD:278594
		ATG16	235..400	CDD:285778
		DUF1664	<289..368	CDD:285172
		TBC	627..849	CDD:214540	77/221 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820