DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and TBC1D8

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_005263919.1	Gene:	TBC1D8 / 11138	HGNCID:	17791	Length:	1162	Species:	Homo sapiens

Alignment Length:	414	Identity:	122/414 - (29%)
Similarity:	196/414 - (47%)	Gaps:	74/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQ----RLQWIAHLEFSHN 136
            |..|:.|..|.:..          |:|..|....:.|:: .|.:...|    |:          :
Human   449 GDLEMMSSQNSEES----------EKEKSPLMHPDALVT-AFQQSGSQSPDSRM----------S 492

  Fly   137 KEAAELS-W-EHV-----DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDI 194
            :|..::| | :|.     .|.:.||||:|.:|..|||.:||.::|:..|.|:.........|.::
Human   493 REQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNL 557

  Fly   195 VKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVA 259
            |:.|.....:.:::||:||.|.||.:..|.|.  |||..|||:|...|...|.|||||...::.:
Human   558 VEESLGKCCLVTEEIERDLHRSLPEHPAFQNE--TGIAALRRVLTAYAHRNPKIGYCQSMNILTS 620

  Fly   260 CLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIE-L 323
            .|||:.:||.|||::..:.|.:|| .|::..::|.|.||.|...||..:|..:.|.:  :|:. |
Human   621 VLLLYTKEEEAFWLLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKGHLPELAEHM--NDLSAL 682

  Fly   324 SLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQD--------------- 373
            :.::|.||||||.:::.::..|.:.|.|||:|...:|||.|.:|:...:|
Human   683 ASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILS 747

  Fly   374 --LKHLEN---------SAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYL 427
              |.|::|         |...|.|....|..|||:..|.|.:.|..|..|...|:..|.:|...:
Human   748 RFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRV 812

  Fly   428 MADQGHQIGNPEAAPNLPKQQLAR 451
            :  |||:        :..||.:.|
Human   813 L--QGHE--------DTTKQNVLR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	77/231 (33%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156
		PH-GRAM2_TBC1D8	318..413	CDD:270160
		TBC	527..733	CDD:214540	75/210 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840