DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and TBC1D3G

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_005276971.1	Gene:	TBC1D3G / 101060321	HGNCID:	29860	Length:	610	Species:	Homo sapiens

Alignment Length:	397	Identity:	88/397 - (22%)
Similarity:	148/397 - (37%)	Gaps:	93/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GPEQ---SSNKLLSIPFVE---------DAQQRLQWIAHLEFSHNKEAAEL--SWEHVDVMLPRT 154
            ||.|   ||:.|..:|:.|         :|:|     ...|.|...:..::  .||    ....:
Human    97 GPLQAPCSSSALPGLPYSETELPPLTAREAKQ-----IRREISRKSKWVDMLGDWE----KYKSS 152

  Fly   155 EKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPT 219
            .||.:...:|:|..:|..||..|......|.|:...| .|:|..........::|::|:...|..
Human   153 RKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRK 216

  Fly   220 NACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPA 284
            :..|.:..||....|..||.......|::|||:....|.|..||::.||:|||.:.    .||.:
Human   217 HMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALV----QLLAS 277

  Fly   285 SYYS---------STLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVH 340
            ..:|         .|:.|:|..|.  |.:..:...::....:| |:......|...:.:..:.:.
Human   278 ERHSLQGFHSPNGGTVQGLQDQQE--HVVATSQPKTMGHQDKK-DLCGQCSPLGCLIRILIDGIS 339

  Fly   341 MKILVRIWDWFFYEGSIVLFQLTLGMLKV--------------------------KEQD--LKHL 377
            :.:.:|:||.:..||...|..:|....||                          :::|  ||||
Human   340 LGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHL 404

  Fly   378 ENS-AQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQI---GNP 438
            ..| .::.....|:|.....         |.|.|.|:.|            .|.:|.:.   |:.
Human   405 RASMKKLTRKQGDLPPPAKP---------EQGSSASRPV------------PASRGGKTLCKGDR 448

  Fly   439 EAAPNLP 445
            :|.|..|
Human   449 QAPPGPP 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	54/250 (22%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
TBC1D3G	XP_005276971.1	TBC	160..373	CDD:214540	53/220 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810