DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc1d12b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_005169505.1	Gene:	tbc1d12b / 100332088	ZFINID:	ZDB-GENE-121214-108	Length:	771	Species:	Danio rerio

Alignment Length:	452	Identity:	103/452 - (22%)
Similarity:	175/452 - (38%)	Gaps:	96/452 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ARSIFGRDHEGYVGREEHTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQ 68
            :||:|.|..     ||..:.....|..:..|.|.||...:....:.   |||...|..|.::...
Zfish   303 SRSLFTRKQ-----REAQSAPGWKLFGKVPLRESPPKDSKTIQQES---NPGNLTSVSTPNLLSS 359

  Fly    69 -EILAKLGGGAELASGP--------------------NDQP--------------EYRFDEFGFR 98
             |..||:....:..|.|                    .|:|              ...:||....
Zfish   360 GEYEAKVCKSGQSPSLPAQSRRKNLEFEPLSTTALILEDRPANLPAKSEEEAQRHRQEYDEMVAE 424

  Fly    99 VEEEDGPE-QSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVR 162
            .::.:..| |...|.:...|.::     :.||:.....|.|... :||    .:..|.::|::..
Zfish   425 AKKRELKEAQKKKKQMKERFKQE-----ESIANAMVVWNTEILP-NWE----SMRGTRRVRDLWW 479

  Fly   163 QGIPHTLRAQMWMRLSG--------------ALAKKQ-KS--ETSYHDIVKASSNDQLMTSKQIE 210
            ||:|..:|.::|....|              :.||:: ||  ||.........|.|:..:...|:
Zfish   480 QGLPPNVRGKVWSLAVGNELNITSDLYEIFLSRAKERWKSFRETGSEIESDVDSADRESSLDLIK 544

  Fly   211 KDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMA 275
            .|:.|..|:...|.. .|.....|..:|.......||:||.||...|.|.|:|.:||.:||...|
Zfish   545 LDISRTFPSLFIFQK-GGPYHDLLHSVLGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFA 608

  Fly   276 TIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSS----VDESL-------RKHDIELSLITLH 329
            .::......:::           ||.|.|:..|.::    .:|:|       :.:::...|..:.
Zfish   609 NLLNKPCQMAFF-----------RVDHELMLKYFAAFEVFFEENLPRLFNHFKSYNLTPDLYLID 662

  Fly   330 WFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLE--NSAQIFNSLSD 389
            |..||:|..:.:.:..|:||.|..:|...||:..||:|::.|:.|..::  :|||....|.|
Zfish   663 WIFTLYAKSLPLDVACRVWDVFCRDGEEFLFRTGLGILRLYEELLLQMDFIHSAQFLTRLPD 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	60/241 (25%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc1d12b	XP_005169505.1	TPX2	407..>451	CDD:284337	6/48 (13%)
tbc1d12b	XP_005169505.1	TBC	478..708	CDD:214540	60/241 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810