DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_002666912.2	Gene:	tbc1d2b / 100330777	ZFINID:	ZDB-GENE-100922-148	Length:	946	Species:	Danio rerio

Alignment Length:	428	Identity:	130/428 - (30%)
Similarity:	205/428 - (47%)	Gaps:	76/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PNDQPEYRFDEFGFRV--EEEDGPEQSSNK-----LLSIPFV-EDAQQRLQWIAHLEFSHNKEAA 140
            ||...||  |.:||:.  ||||..|:...|     |.|:... ::...|::|..:|..:.|:|
Zfish   571 PNAVSEY--DIYGFKTVPEEEDEEEKLEAKKRALDLKSLSLTDQETSVRVKWDNYLAITMNRE-- 631

  Fly   141 ELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKS---ETSYHDIVKASSNDQ 202
                      :.|:..|:.::|.|:||..|:::|........||.:.   :..||:::..:::..
Zfish   632 ----------MVRSPDLKALMRGGVPHIHRSKVWSWCVSFHVKKMRDCQPKDYYHNLLCMANDKP 686

  Fly   203 LMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEE 267
            ....||||.||||.||.|..:|:|:..||.:||.:|...:|..||||||||...:.|..||::::
Zfish   687 NPACKQIELDLLRTLPNNKHYSSPDSDGIQKLRNVLLAFSWRNPDIGYCQGLNRLAAIALLYLDQ 751

  Fly   268 ENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFL 332
            |:|||.:..|||..:|..||:.||||.|.||||...|:...|..:......:.::.||||.:|||
Zfish   752 EDAFWCLVAIVEVFMPHDYYTKTLLGSQVDQRVFKDLMYEKLPRLHAHFEHYKVDFSLITFNWFL 816

  Fly   333 TLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDV 397
            .:|.:.|...||.:|||.|.|||..::|:..|.:.|.||::...|::...||..|.
Zfish   817 VVFVDSVVSDILFKIWDSFLYEGPKIIFRFALALFKYKEEEFLKLQDPMTIFKYLR--------- 872

  Fly   398 EVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARR------QVRK 456
                        ..::|::|.  |:.:|....|.     ||     .|.:|:..|      :||.
Zfish   873 ------------YFTRTILDA--RKLMAMAFVDM-----NP-----FPLRQIQNRRTFHLEKVRL 913

  Fly   457 SKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAI 494
            ..:.|||            ::...:|:.|..:|.|..|
Zfish   914 ELTELEA------------IRQTFLRERESTMDGRTLI 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	84/216 (39%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457
		TPR_MLP1_2	313..434	CDD:285204
		USP8_interact	317..>359	CDD:286082
		TBC	643..859	CDD:214540	84/215 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820