DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc1d8b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001107709.2	Gene:	tbc1d8b / 100101803	XenbaseID:	XB-GENE-923435	Length:	1119	Species:	Xenopus tropicalis

Alignment Length:	678	Identity:	166/678 - (24%)
Similarity:	276/678 - (40%)	Gaps:	179/678 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SSNKLLSIPFVEDAQQRLQWIAHLEFSHNKE-AAELSWEHV------DVMLPRTEKLRNMVRQGI 165
            |:..|:::...:||:       :|:....|| ..|.:|:.:      .|.:.||:|.||:|.:||
Frog   426 STEALMTVFHPQDAE-------NLDTKMLKEKMKEQTWKILFTECGRGVSMFRTKKTRNLVVRGI 483

  Fly   166 PHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTG 230
            |.|||.::|:..|||:.....:...|.:||:.|.....:.:.:||:||.|.||.:..|.  :.||
Frog   484 PETLRGELWLLFSGAVNDMAANPGYYTEIVEKSLGTCTLATDEIERDLRRSLPEHPAFQ--SDTG 546

  Fly   231 IPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQ 295
            |..|||:|...|:..|.|||||...::.:.|||:.:||.|||::..:.|.:|| .|::..::|..
Frog   547 ISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGAL 610

  Fly   296 ADQRVMHTLIANYLSSVDESLRKHDIE-LSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVL 359
            .||.|...||..||..:...:.  ||. .|.::|.||||||.:|:.::..|.:.|.|||:|...:
Frog   611 VDQAVFEELIKEYLPLLTSHMT--DITFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAI 673

  Fly   360 FQLTLGMLKVKEQDLKHLENSAQ-----------IFNSLSDIPGEV---------------TDVE 398
            .||.|.:|....:.|...::.|:           :.|..|.:|..|               .|:.
Frog   674 LQLGLVVLDFNMEKLLACKDDAEAVTILNRFFDNVVNKDSPLPSSVQQAPTGAEGKPTGTKVDIT 738

  Fly   399 VLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLAR---RQVRKSKSI 460
            .|.|:|.|..|::....:::.|.|:..|::          :......:|.:.|   :.|:.|.:.
Frog   739 DLIREANEKFGAIRYEDVESMRSRNRLYVI----------QTLETTTRQNVVRVVLQDVKFSPAD 793

  Fly   461 LEA--FLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFI----TIEPKLAGHIQLTANYS 519
            ||.  :||:                       ||       ||:    |:...:..|...:..|.
Frog   794 LEELYYLFK-----------------------RE-------HFLSCYWTVNSSILSHHDPSLPYL 828

  Fly   520 TESHAKDHENFINVARTR-------------KRRAKALHDFERHDDDELGFRRNDIITIISQKDE 571
            .:.|       ||..:.|             ...:.||..|...|::..||        |:.| |
Frog   829 EQYH-------INCQQFRTLYHLLCPWAYSANADSLALWTFRLLDENMDGF--------INFK-E 877

  Fly   572 HCWVGELNGLRGWFPAKFVELLDERSKL---------YTSAGDDAISE----TVTDLV------- 616
            ..:.         |...:.....:|.||         :|..|..:.||    :..||:
Frog   878 FAFA---------FDVMYNRSFTDRLKLLFKIHIPPAFTEVGSISPSEEAKLSKEDLMHFSNLHI 933

  Fly   617 ---RGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEE-----AATREVEKDF------ESVYSRL 667
               :..|:|.::.      |.|....|.|....|:::     |...|..||.      :.::...
Frog   934 TSPKENLSPEVQT------KSPEKGRGKIDIQAYLKQWQDELARKEESIKDLPRINQTQFIHFSK 992

  Fly   668 VLCKTYRLDEDGKVLTPEELLYRCVQAI 695
            .|...:..|.:      ||||||.:.|:
Frog   993 TLYNLFHGDPE------EELLYRAIAAV 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	78/214 (36%)
		SH3_SGSM3	540..592	CDD:212747	10/51 (20%)
		RUN	619..773	CDD:280855	20/88 (23%)
tbc1d8b	NP_001107709.2	PH-GRAM1_TBC1D8B	155..253	CDD:275419
		PH-GRAM2_TBC1D8B	295..387	CDD:270159
		TBC	481..689	CDD:214540	77/212 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030