Protein Alignment SIDL and TRAPPC10

DIOPT Version :10

• Sequence 1: NP_650431.1
• Gene: SIDL / 41833
• FlyBaseID: FBgn0038303
• Length: 1145
• Species: Drosophila melanogaster
• Sequence 2: XP_011528016.1
• Gene: TRAPPC10 / 7109
• HGNCID: 11868
• Length: 1296
• Species: Homo sapiens
• Alignment Length: 1319
• Identity: 379/1319 - (28%)
• Similarity: 619/1319 - (46%)
• Gaps: 227/1319 - (17%)

  Fly     1 MQIKPIITYSGSCPLFRSLESQILNAIPLDTCEWRRTFQRPTKHVRLEAQAQQFNVAALEKYKQG 65
            |:.|||:|.:|...||.|:...:...:|.:..||||::.|..|.:.||:...||....|.  |:|
Human    15 MENKPIVTCAGDQNLFTSVYPTLSQQLPREPMEWRRSYGRAPKMIHLESNFVQFKEELLP--KEG 77

  Fly    66 DWSILEHPILHIFVTECNDVDTYKATIREAIDIWLKTLTSYGVSDWMILLVETLDMRKTK-NFMP 129
            :.::|..|.|||:.|||.|.:.||||:::.:..|...|.::...||:|::||....:|.| |.:|
Human    78 NKALLTFPFLHIYWTECCDTEVYKATVKDDLTKWQNVLKAHSSVDWLIVIVENDAKKKNKTNILP 142

  Fly   130 RTTVLDKIRLDFGTKNDDRCISVLNPAKFEQKSTESFRCLVQRIRFLMLTSYNRNIVKYEELIRS 194
            ||:::||||.||..|..|||:.:.:|.|...::.||:...:.::|.|:|.|:.:|:.|:|:.:|:
Human   143 RTSIVDKIRNDFCNKQSDRCVVLSDPLKDSSRTQESWNAFLTKLRTLLLMSFTKNLGKFEDDMRT 207

  Fly   195 KREKRNIEGWDFRQYFFMQEDLALIFEKLELPTEALIQYDELDAMFSQFITHTGLNEKQQWLNHF 259
            .||||...||.|.:||.:||:||.:||.|:...:||:|||||||:|||::.:.|..:...||..|
Human   208 LREKRTEPGWSFCEYFMVQEELAFVFEMLQQFEDALVQYDELDALFSQYVVNFGAGDGANWLTFF 272

  Fly   260 RKPLDAFHGICLTRADKFEMRNKIRDEGVSLLEFRNYLFERQAYLLLTCNDIPEIAKRLLNFLFS 324
            .:|:.:::|:.|.:....|.|..|:....:||:.|:|||.||..|||......|:|:|.|..|.:
Human   273 CQPVKSWNGLILRKPIDMEKRESIQRREATLLDLRSYLFSRQCTLLLFLQRPWEVAQRALELLHN 337

  Fly   325 TLREVELIKLECQEGALCCWEFVCALEVLQ----LCEQAMEPNELTCFQHCAPIWNLAKDKLYEL 385
            .::|::|:::....|||.||.|:..|||||    .|::|...:.:.   |...:|:.|.:||..|
Human   338 CVQELKLLEVSVPPGALDCWVFLSCLEVLQRIEGCCDRAQIDSNIA---HTVGLWSYATEKLKSL 399

  Fly   386 GKLCGLLPGCTPTSEQLHIVVQLSSGIGDAPSEQHQFLQATPQLRDRSPNRKPKKSGAEQLKEAL 450
            |.||||:....|.||.|:..|.|.:|:|....|.....|        ||.:|        |||||
Human   400 GYLCGLVSEKGPNSEDLNRTVDLLAGLGAERPETANTAQ--------SPYKK--------LKEAL 448

  Fly   451 GSNQAFQKLYLELAELAISTYKHVTRLRSARLVGLDLGNFYCALNEPHKAVGFFTDLLRELKAEN 515
            .|.:||:|.||:|:...|..|..:.|:|||:.||.||..||.....|.||..:....|:...||.
Human   449 SSVEAFEKHYLDLSHATIEMYTSIGRIRSAKFVGKDLAEFYMRKKAPQKAEIYLQGALKNYLAEG 513

  Fly   516 WHMLSSQTLLELANCYRKMGDSLAYTKTCSSISCCAELETLVRTFYFDEFLKSLKTLKTTLSAQP 580
            |.:..:.|..:||.|.:.:|....|.:|.|.::....|....|..:..|.|        ..::||
Human   514 WALPITHTRKQLAECQKHLGQIENYLQTSSLLASDHHLTEEERKHFCQEIL--------DFASQP 570

  Fly   581 SIENANYCVLEDH--FRILDIEVVNQKPIIQDDYIL-VQLKVESLYPRGVVAEN--VKLCYELEA 640
            |....:..||..|  .::.|:.......::....:| |::.:.|..|..|..|.  |.:.:.:|.
Human   571 SDSPGHKIVLPMHSFAQLRDLHFDPSNAVVHVGGVLCVEITMYSQMPVPVHVEQIVVNVHFSIEK 635

  Fly   641 SSLELAME--------NVSLTASPSTVKAKDTSSRLKVSLQLVYK------QDNRLHSAAVACDL 691
            :|.....|        |..:...|.|.....:.:.|. :|:| |:      .||.|::..:.|
Human   636 NSYRKTAEWLTKHKTSNGIINFPPETAPFPVSQNSLP-ALEL-YEMFERSPSDNSLNTTGIIC-- 696

  Fly   692 PKSKQPVRRTSSTKRKLSPSVQA--DFTNFVQAENIALQPGVNLIEMKAKATRVGCWQFKQLCIS 754
            ......:||..|:.....||..|  :..:.::..::.|:||.|.|..:.:|...|.:..:|||.|
Human   697 RNVHMLLRRQESSSSLEMPSGVALEEGAHVLRCSHVTLEPGANQITFRTQAKEPGTYTLRQLCAS 761

  Fly   755 MSSLEFL---------------SEQLPFMPATFEISTK-------PAS--ATLEFK--------- 786
            :.|:.|:               ..||...|...:...:       |||  :.|:|.
Human   762 VGSVWFVLPHIYPIVQYDVYSQEPQLHVEPLAEDFWAQMCRDFPLPASKQSVLQFSSDPVYWSWR 826

  Fly   787 -----TLIAGIVQPISLNVSGGSFIFPPDAKITLRCSKNLRIRQA-------------------R 827
                 :|:|||.|.:...|:.|.:        |::...:|::..|                   |
Human   827 QTPQDSLLAGIPQRVKFTVTTGHY--------TIKNGDSLQLSNAEAMLILCQAESRAVVYSNTR 883

  Fly   828 NTDDEAAYNDDQSFESTLQVPLVQFKSFEERRIPLEVL-----------TDM-----PGRKVSKH 876
            ....|||.. .||.:....:.|....::......||||           :||     |.||....
Human   884 EQSSEAALR-IQSSDKVTSISLPVAPAYHVIEFELEVLSLPSAPALGGESDMLGMAEPHRKHKDK 947

  Fly   877 H---------EHHIALNCPWSRTELPIAVDFQPAMEATCRLHTCGTQKFLQVIMKGM-EAHLLLQ 931
            .         :|.::::||||.....||:.|......|..|.:.||:|::||.::.: |....|.
Human   948 QRTGRCMVTTDHKVSIDCPWSIYSTVIALTFSVPFRTTHSLLSSGTRKYVQVCVQNLSELDFQLS 1012

  Fly   932 HAQV--KCDVPGVQLLDLNPESQQPIEIYKSLTVTYLYEIQVEPLKTEHELPVVKVHFVIKYASL 994
            .:.:  ..|...:||:.||.:||||  ||...:|.:::|::    .||...|.:...|.:.::..
Human  1013 DSYLVDTGDSTDLQLVPLNTQSQQP--IYSKQSVFFVWELK----WTEEPPPSLHCRFSVGFSPA 1071

  Fly   995 SQPDV---WRTYGCAFDLVDYTTLFKLQAQLEP---NELCRLRTVCNMNLKITKV---------- 1043
            |:..:   .:.|...|.:.::.||:.::|::.|   .|.||..::|::.:.||::
Human  1072 SEEQLSISLKPYTYEFKVENFFTLYNVKAEIFPPSGMEYCRTGSLCSLEVLITRLSDLLEVDKDE 1136

  Fly  1044 -----HENPYTDLMYEVLNDQNLWAVCGRSAGVVSMKDV--DSHSISLDVMPLSTGFLPMPSIRL 1101
                 .|:..|.|||||:::.:.|||||:|.||:||...  .:|.:.::||||..|:||:|.:||
Human  1137 ALTESDEHFSTKLMYEVVDNSSNWAVCGKSCGVISMPVAARATHRVHMEVMPLFAGYLPLPDVRL 1201

  Fly  1102 SKY---------------------------------TAGGKSKTDGHS------------KVHPF 1121
            .||                                 ::..||:...||            ::...
Human  1202 FKYLPHHSAHSSQLDADSWIENDSLSVDKHGDDQPDSSSLKSRGSVHSACSSEHKGLPMPRLQAL 1266

  Fly  1122 PPGQVYNSTKSMQIHVIAS 1140
            |.|||:||:...|:.||.|
Human  1267 PAGQVFNSSSGTQVLVIPS 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIDL	NP_650431.1	TRAPPC10	980..1138	CDD:403698	56/225 (25%)
TRAPPC10	XP_011528016.1	TRAPPC10	1106..1283	CDD:403698	47/176 (27%)