DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIDL and trappc10

DIOPT Version :9

Sequence 1:	NP_650431.1	Gene:	SIDL / 41833	FlyBaseID:	FBgn0038303	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	XP_002663888.2	Gene:	trappc10 / 100334988	ZFINID:	ZDB-GENE-131115-1	Length:	1254	Species:	Danio rerio

Alignment Length:	1299	Identity:	362/1299 - (27%)
Similarity:	601/1299 - (46%)	Gaps:	231/1299 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQIKPIITYSGSCPLFRSLESQILNAIPLDTCEWRRTFQRPTKHVRLEAQAQQFNVAALEKYKQG 65
            |:.|||:||:|...||.:|.:.:...:|.:..||||::.|..|.:.|||...||....|.  |:|
Zfish    13 MENKPIVTYAGDQTLFTALYTSLTQQLPREPMEWRRSYGRAPKMIYLEANFVQFKEELLP--KEG 75

  Fly    66 DWSILEHPILHIFVTECNDVDTYKATIREAIDIWLKTLTSYGVSDWMILLVETLDMRKTK-NFMP 129
            :.::|..|.|||:.|:|.|.:.|||:::|.:..|...|..:|.:||:|::||..:.:|.| |.:|
Zfish    76 NKALLTFPFLHIYWTDCCDTEVYKASVKEDMQRWQGVLRLHGSADWLIVVVENDNKKKNKTNILP 140

  Fly   130 RTTVLDKIRLDFGTKNDDRCISVLNPAKFEQKSTESFRCLVQRIRFLMLTSYNRNIVKYEELIRS 194
            ||::|||||.||..|..|||:|:..|.|...:|.||:...:.::|.|:|.|:.||:.::|:.:|:
Zfish   141 RTSILDKIRNDFCNKQSDRCVSLSEPLKESSRSQESWSSFLTKLRTLLLMSFTRNLGRFEDDMRT 205

  Fly   195 KREKRNIEGWDFRQYFFMQEDLALIFEKLELPTEALIQYDELDAMFSQFITHTGLNEKQQWLNHF 259
            .||||...||.|..||.:||:||.:||.|:...:||:|||||||:|:|::.:.|..:...||..|
Zfish   206 LREKRTEPGWSFCDYFMVQEELAFVFEMLQQFEDALVQYDELDALFTQYVLNFGAGDGANWLCSF 270

  Fly   260 RKPLDAFHGICLTRADKFEMRNKIRDEGVSLLEFRNYLFERQAYLLLTCNDIPEIAKRLLNFLFS 324
            .:|:.:::|:.|.|....|.|:.|:....|||:.|:|||.||..||:......|:..|.|..|.:
Zfish   271 CQPVRSWNGLLLRRPIDMEKRDLIQRGDASLLDLRSYLFSRQCTLLIFLQRPWEVTARALELLHT 335

  Fly   325 TLREVELIKLECQEGALCCWEFVCALEVLQLCEQAMEPNELTC-FQHCAPIWNLAKDKLYELGKL 388
            .::|:.|:::....|||.||.|:..||||...|...|.::|.. :.|...:|..|.:||..||.|
Zfish   336 CVQELRLLEVSVVCGALDCWVFLSCLEVLHRIEGCCERSQLEANYSHTVGLWTYATEKLKALGDL 400

  Fly   389 CGLLPGCTPTSEQLHIVVQLSSGIGDAPSEQHQFLQATPQLRDRSPNRKPKKSGAEQLKEALGSN 453
            |||:....|.||.|:..|.|.:|:|...:|..|.||        ||.:|        |||||.|.
Zfish   401 CGLVSENGPNSEDLNRTVDLLAGLGAERAETAQSLQ--------SPYKK--------LKEALSSV 449

  Fly   454 QAFQKLYLELA-------------------ELAISTYKHVTRLRSARLVGLDLGNFYCALNEPHK 499
            :||:|.||..|                   ...||.:..|..||.               .:|..
Zfish   450 EAFEKHYLVSAPSHHLCARVCVCVXVSVCLTAVISRFISVAHLRK---------------GDPQS 499

  Fly   500 AVGFFTDLLRELKAENWHMLSSQTLLELANCYRKMGDSLAYTKTCSSISCCAELETLVRTFYFDE 564
            |..|..|.|:...:|:|.:..:.|..::|.|.:::.....|.:|.:.::....|....|..:..|
Zfish   500 AELFLLDSLKSFVSESWSLPLTHTRRQIAECQKQLQKMDEYLQTSALLASDTNLSHEERKHFCQE 564

  Fly   565 FLKSLKTLKTTLSAQP--------SIENANYCVLEDHFRILDIEVVNQKPIIQDDYILVQLKVES 621
            .|        |.::||        |:..::..||::........||:....:|     ::|.|.|
Zfish   565 IL--------TFASQPEGKGQAKVSLSMSSLGVLQELIFCPASAVVHVGAELQ-----MELHVCS 616

  Fly   622 LYPRGVVAENVKLCYELEASSLELAME------NVSLTASPSTVKAKDTSSRLKVSLQL-----V 675
            |.|       :.:|.:..:::|..:.:      ..:..||.|.|....:...:..:|:|     :
Zfish   617 LQP-------LPVCVQQFSAALHFSTDPPGTHRRSAQQASGSVVFPALSPVSVSPALELCEVTEL 674

  Fly   676 YKQDNRLHSAAVACDLPKS-----KQPVRRTS-STKRKLSPSVQADFTNFVQAENIALQPGVNLI 734
            ...|:.|.||.|||   |:     ::|...|| .|....:.|...:..:.::|.:|.||||.|.|
Zfish   675 SPSDSALSSAGVAC---KNTHLLMRRPDSATSLQTGGTAATSALEEAEHMLRATDITLQPGHNTI 736

  Fly   735 EMKAKATRVGCWQFKQLCISMSSLEFLSEQLPFMPATFEISTKPASATLEFKT--LIAGIVQPIS 797
            ...|.:.:.|.:..:|||.::..::|:...| :....:|:.::....:::..|  |:||:.|.:.
Zfish   737 SFSAPSQKPGTYTLRQLCATLGRVQFVLPHL-YPVVQYEVYSQEPQLSIQPLTECLLAGLPQQVQ 800

  Fly   798 LNVSGGSFIFPPDAKITL------------RCSKNLRIRQARNTDD---EAAYNDDQSFESTLQV 847
            ..:..|.:.......:.|            .||..:|    .::.|   |:|.: .||.|....:
Zfish   801 FCIQTGHYSVKKGDALQLSNTDSMPVLHTHTCSARIR----NSSGDVVCESALS-IQSSEKVTSI 860

  Fly   848 PLVQFKSFEERRIPLEVLTDMPGRKVSKHHE---------------------------HHIALNC 885
            .|....::......||||..:|...|:...|                           ..::::|
Zfish   861 SLPATPAYHTLEFQLEVLCRIPACPVAARVESERLTNGQISHRARSRTRYSSGTAIIDQKVSIDC 925

  Fly   886 PWSRTELPIAVDFQPAMEATCRLHTCGTQKFLQVIMKGM---EAHLLLQHAQVKCDVPGVQLLDL 947
            |||.....:::.|....:....|.|.|.:||:||.::.:   ...|..|......|.|.::||.|
Zfish   926 PWSIYSTLVSLTFHVPFKVKHSLLTAGRRKFVQVCLQNVSDTNFRLTNQTLTENQDTPSLELLSL 990

  Fly   948 NPESQQPIEIYKSLTVTYLYEIQVEPLKTEHELPVVKVH--FVIKYASLSQPDV-WRTYGCAFDL 1009
            |.::.  ..::....|..::|::..      :.|.|.:.  |...:|....||. .:.|...|.|
Zfish   991 NTKTH--CVVFSQQCVFSVWELRWS------DAPPVSLQCVFSASFAPADAPDTHLKPYTHQFSL 1047

  Fly  1010 VDYTTLFKLQAQLEP---NELCRLRTVCNMNLKITKVHEN--------PYTD--------LMYEV 1055
            ...:|::.::|.:.|   :..||..::|.:.:.||::.|:        .|:|        |:|||
Zfish  1048 ERVSTVYSVRADISPAAGDGECRCGSLCRLEVSITRLTEHTDAERSDEEYSDTDGLRTCRLLYEV 1112

  Fly  1056 LNDQNLWAVCGRSAGVVSMKD--VDSHSISLDVMPLSTGFLPMPSIRLSKY---TAGGKSKTDGH 1115
            :::.:.|||||:|:|||||..  :.:|.:.:::|||..|.||.|||||.:|   .|....:.|..
Zfish  1113 MDNSSNWAVCGKSSGVVSMPTAAMATHKVQMEIMPLFAGSLPFPSIRLFRYLPHQANASVQPDSD 1177

  Fly  1116 SKVH-----------------------------------PFP------PGQVYNSTKSMQIHVI 1138
            |.|.                                   |.|      |.||::||:|.|:.|:
Zfish  1178 SCVESDSVSVVERGVEECDSASVRSRSSVCSSSDGPRGLPMPRRQALGPAQVFSSTQSRQVRVL 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIDL	NP_650431.1	TRAPPC10	978..1138	CDD:289361	61/227 (27%)
trappc10	XP_002663888.2	TRAPPC10	1016..1241	CDD:289361	61/224 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574379
Domainoid	1	1.000	368	1.000	Domainoid score	I868
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37751
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1742
OMA	1	1.010	-	-		QHG46353
OrthoDB	1	1.010	-	-		D107574at33208
OrthoFinder	1	1.000	-	-		FOG0003974
OrthoInspector	1	1.000	-	-		oto39514
orthoMCL	1	0.900	-	-		OOG6_104539
Panther	1	1.100	-	-	LDO	PTHR13251
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5793
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910