DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF432

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001309213.1	Gene:	ZNF432 / 9668	HGNCID:	20810	Length:	652	Species:	Homo sapiens

Alignment Length:	604	Identity:	174/604 - (28%)
Similarity:	258/604 - (42%)	Gaps:	118/604 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 PNALP-----EEP----DSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLI 136
            |:||.     |||    |.:.|..||             |.:.....:|       |..:|..::
Human    54 PDALSKLERGEEPWTMEDERHSRICP-------------ENNEVDDHLQ-------DHLENQRML 98

  Fly   137 KSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQ 201
            ||     ::...|...|     .....:|.||.|..:.:...|..:...::|:       .|..|
Human    99 KS-----VEQYHEHNAF-----GNTASQTKSLCLFRENHDTFELYIKTLKSNL-------SLVNQ 146

  Fly   202 IREC---NLAIFEG------VDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARE 257
            .:.|   |...|.|      ..|..|:.:.....|:|:.::    |:.:..|||       ...|
Human   147 NKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFSVSTKANS----TKSQVSKHQ-------RTHE 200

  Fly   258 LEKEQV--------PQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKL---------- 304
            :||..|        .:.::.|...| |...:.|......|:...::.||...:::
Human   201 IEKNHVCSECGKAFVKKSQLTDHER-VHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICS 264

  Fly   305 SAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFV 368
            ...:..|:...........|.|..|.|:.|..||..:::|::|:| ..|  .::|.|:||.|.|.
Human   265 ECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTG--EKSYICSECGKGFT 327

  Fly   369 SPDHLAEHQASHGAHN---CPECGIRCDSKEALSKHMVQGHKRNLRNQ----CNICQKVFTMLST 426
            ....|..||.:|....   |.|||     |...:||.|..|:||...:    ||.|.|.|||.|.
Human   328 GKSMLIIHQRTHTGEKPYICSECG-----KGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSR 387

  Fly   427 LRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHT 491
            :.:|.|.||||||::|:.|||.|.:.:||..|:..|:..||:.|..|...|..|:.|..|.||||
Human   388 MIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRTHT 452

  Fly   492 GDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPF 556
            |:||:.|..|...|.....|..|:|.||||:||.|..|...|...:.|..|:||||||:||:|..
Human   453 GEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNE 517

  Fly   557 CSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQ---HDKRLVHFTFLSNK 618
            |.|.|..:.:..:|||||.||:.::|..|.:.|    .|:.:|..|:|   .:|..:      ..
Human   518 CGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGF----TMKRYLIVHQQIHTEEKSCI------CS 572

  Fly   619 ENGSGALEEELNEMTESAL 637
            |.|.|..:|     ||.||
Human   573 ECGRGFAKE-----TELAL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	90/219 (41%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF432	NP_001309213.1	KRAB	8..68	CDD:214630	6/13 (46%)
		KRAB	8..47	CDD:279668
		COG5048	<87..380	CDD:227381	74/335 (22%)
		C2H2 Zn finger	207..227	CDD:275368	2/20 (10%)
		C2H2 Zn finger	235..255	CDD:275368	3/19 (16%)
		COG5048	259..636	CDD:227381	125/350 (36%)
		C2H2 Zn finger	263..283	CDD:275368	1/19 (5%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		zf-H2C2_2	331..356	CDD:290200	9/29 (31%)
		C2H2 Zn finger	347..367	CDD:275368	10/24 (42%)
		C2H2 Zn finger	375..395	CDD:275368	10/19 (53%)
		C2H2 Zn finger	403..423	CDD:275368	8/19 (42%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..466	CDD:290200	11/22 (50%)
		C2H2 Zn finger	459..479	CDD:275368	6/19 (32%)
		zf-H2C2_2	472..494	CDD:290200	11/21 (52%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		zf-H2C2_2	500..523	CDD:290200	13/22 (59%)
		C2H2 Zn finger	515..535	CDD:275368	7/19 (37%)
		zf-H2C2_2	527..551	CDD:290200	10/27 (37%)
		C2H2 Zn finger	543..563	CDD:275368	7/23 (30%)
		C2H2 Zn finger	571..591	CDD:275368	8/21 (38%)
		C2H2 Zn finger	599..619	CDD:275368
		zf-H2C2_2	612..636	CDD:290200
		C2H2 Zn finger	627..647	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910