DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF845

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	493	Identity:	152/493 - (30%)
Similarity:	209/493 - (42%)	Gaps:	92/493 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 QGNLKDEKEVVFTQTNVIYE----GD--DHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRK 231
            |||    .||:.|.|...:|    ||  ..|:|:.|.:     ||....|.|..:..||.
Human    63 QGN----TEVIHTGTLQRHERHHIGDFCFQEMEKDIHD-----FEFQWKEDERNSHEAPM----- 113

  Fly   232 SAAKLLTQQENDKHQTPVGSK------------------------EEARELEKEQVPQSAKRTSR 272
            :..|.||...|...|...|:|                        :...::||.....|...||:
Human   114 TEIKQLTGSTNRHDQRHAGNKPIKDQLGSSFHSHLPELHMFQTEGKIGNQVEKSINSASLVSTSQ 178

  Fly   273 RRGVVKQDVPATPPSDAEP------------SPKQHRLGTQRKLSAPRAGTVNGPSTT------- 318
            |       :...|.:....            :.||.....::......:|.....|:.
Human   179 R-------ISCRPKTHISKNYGNNFLNSSLLTQKQEVHMREKSFQCNESGKAFNYSSVLRKHQII 236

  Fly   319 -SGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHG 381
             .||.     :|.||.|...|..::.|..||| ..|  .:.||||:|.|.|.....|..|...|.
Human   237 HLGAK-----QYKCDVCGKVFNQKRYLACHRRCHTG--KKPYKCNDCGKTFSQELTLTCHHRLHT 294

  Fly   382 A---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCN 443
            .   :.|.|||.......||..|... |......:||.|.|.|:..|.|..|.|:||||||:.|.
Human   295 GEKHYKCSECGKTFSRNSALVIHKAI-HTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCE 358

  Fly   444 ICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
            .|.|:|:..:||.:|:..|:..|.:||..|..:|..|:.||.|.|.|||:||::|..|...|:..
Human   359 ECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTFSQM 423

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            .||..|:|.||||:||.|:.|...|:..:.|:.|||.||||:||.|..|.|||:|......|:|.
Human   424 SSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRL 488

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLVH 611
            |.||:.|.|..|:|.|    ..:|:|..|     |::|
Human   489 HTGEKPYKCEECDEAF----SFKSNLERH-----RIIH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/23 (39%)
		COG5048	<357..570	CDD:227381	88/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	124/373 (33%)
		C2H2 Zn finger	217..237	CDD:275368	2/19 (11%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	7/20 (35%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	9/24 (38%)
		COG5048	381..813	CDD:227381	62/146 (42%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..478	CDD:290200	15/24 (63%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	8/28 (29%)
		zf-H2C2_2	509..534	CDD:290200	4/14 (29%)
		C2H2 Zn finger	525..545	CDD:275368
		zf-H2C2_2	537..560	CDD:290200
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		zf-H2C2_2	649..674	CDD:290200
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		zf-H2C2_2	761..786	CDD:290200
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910