DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF765

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001035275.1	Gene:	ZNF765 / 91661	HGNCID:	25092	Length:	523	Species:	Homo sapiens

Alignment Length:	371	Identity:	115/371 - (30%)
Similarity:	169/371 - (45%)	Gaps:	53/371 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PKQHRLGTQRKLSAPRAGTVNGPSTTSGA---ATTPEL----KYHCDRCNAGFAVEKSLMIHRRQ 350
            |:.|...|:.|:......:::..|..|.|   :..||.    .|..:..|:....:|. .:|.|:
Human   149 PELHIFHTEEKIDNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQ-EVHMRE 212

  Fly   351 K-----------GCIN------------RNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECG 389
            |           .|.:            :.|||:.|.|||.|..::|.|:..|..   :.|.|||
Human   213 KSFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECG 277

  Fly   390 IRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNAN 454
            ........|:.|. :.|......:|..|.|.|...|.|:.|.||||||||:.||.|||:|:|.:.
Human   278 KTFSQTYYLTCHR-RLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSY 341

  Fly   455 LRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHT 519
            |..|:..|:..|.:||..|..:|..|:..|.|.|.|||:||::|..|...|:...||..|:|.||
Human   342 LTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHT 406

  Fly   520 GERPYACDLCPMRFT---ALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYI 581
            .|:||.|:.|...|.   .||:.    |.|:||:||.|..|.|.::.:.:.::||:.|..|..|.
Human   407 EEKPYKCNECGKTFNQQLTLNIC----RLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPYK 467

  Fly   582 CPVCNEEFKSMPEMRSHLAGHEQHDKRLVH--------FTFLSNKE 619
            |..|.:.|.....:..|   |..|..:..:        |:|.||.|
Human   468 CNECGKTFSRTSSLTYH---HRLHTGQKPYKCEDCDEAFSFKSNLE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	5/33 (15%)
		COG5048	<357..570	CDD:227381	83/218 (38%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/22 (27%)
		zf-H2C2_2	539..563	CDD:290200	9/23 (39%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF765	NP_001035275.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368	1/19 (5%)
		zf-H2C2_2	230..254	CDD:290200	7/23 (30%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	260..282	CDD:290200	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	6/20 (30%)
		zf-H2C2_2	285..309	CDD:290200	6/24 (25%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	314..338	CDD:290200	16/23 (70%)
		COG5048	<325..477	CDD:227381	60/155 (39%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	341..366	CDD:290200	8/24 (33%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	440..460	CDD:275368	5/19 (26%)
		zf-H2C2_2	452..477	CDD:290200	8/24 (33%)
		C2H2 Zn finger	468..488	CDD:275368	5/22 (23%)
		C2H2 Zn finger	496..515	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910