DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF616

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	289	Identity:	112/289 - (38%)
Similarity:	148/289 - (51%)	Gaps:	23/289 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELKYHCDRCNAGFAVEKSLMIHRR----QKGCINRNYKCNECEKVFVSPDHLAEHQASH---GAH 383
            |.:|.|:.|...|:...||.:|||    :|.|     |||||.|||.....||.||..|   ..:
Human   378 EKQYKCNECGKVFSKRSSLAVHRRIHTVEKPC-----KCNECGKVFSKRSSLAVHQRIHTGQKTY 437

  Fly   384 NCPECGIRCDSKEALSKHMVQG-----HKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCN 443
            .|.:||      :..|||....     |......:||.|.|||::.|.|..|.||||||||:.||
Human   438 KCNKCG------KVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCN 496

  Fly   444 ICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
            .|||.|:|::.|..|:..|:..|.:||:.|...|..::....|.|.|||:||::|:.|...|:..
Human   497 ECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGEKPYKCKECGKVFSQC 561

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            ..|..|:|.|:||:||.|:.|...::..:.|..|||.||||:||.|..|.|.|.|......|||.
Human   562 SRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHTGEKPYKCHECGKAFNQGSTLNRHQRI 626

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            |.||:.|.|..|...|.....:|.|...|
Human   627 HTGEKPYKCNQCGNSFSQRVHLRLHQTVH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/26 (35%)
		COG5048	<357..570	CDD:227381	87/220 (40%)
		C2H2 Zn finger	360..380	CDD:275368	11/19 (58%)
		C2H2 Zn finger	385..406	CDD:275370	6/25 (24%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	3/16 (19%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129
		C2H2 Zn finger	187..207	CDD:275368
		zf-H2C2_2	199..224	CDD:290200
		C2H2 Zn finger	243..263	CDD:275368
		COG5048	266..707	CDD:227381	112/289 (39%)
		C2H2 Zn finger	271..291	CDD:275368
		zf-H2C2_2	283..308	CDD:290200
		C2H2 Zn finger	299..319	CDD:275368
		zf-H2C2_2	311..336	CDD:290200
		C2H2 Zn finger	327..347	CDD:275368
		C2H2 Zn finger	355..375	CDD:275368
		C2H2 Zn finger	383..403	CDD:275368	8/19 (42%)
		C2H2 Zn finger	411..431	CDD:275368	11/19 (58%)
		C2H2 Zn finger	439..459	CDD:275368	6/25 (24%)
		C2H2 Zn finger	467..487	CDD:275368	10/19 (53%)
		zf-H2C2_2	480..504	CDD:290200	16/23 (70%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	508..531	CDD:290200	7/22 (32%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	538..560	CDD:290200	10/21 (48%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..616	CDD:290200	14/24 (58%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		zf-H2C2_2	620..644	CDD:290200	10/23 (43%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		zf-H2C2_2	647..672	CDD:290200	3/9 (33%)
		C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910