DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF559

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	619	Identity:	157/619 - (25%)
Similarity:	232/619 - (37%)	Gaps:	191/619 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ISCPVATTDQ--AVQTTSWEPDRCTASVQT----DAVTTTDAEQNTSLIKSTISVDLDYEGEGEV 152
            :|||...:..  .:..:.:|.:|..|...|    |:||..|           ::||...|
Human    42 LSCPDHLSQDVFCLHESKFEEERMVAGWLTNYSQDSVTFED-----------VAVDFTQE----- 90

  Fly   153 FDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEA 217
             ::.|.|:                        ||.| :|.  |..||      |......||.|:
Human    91 -EWTLLDQ------------------------TQRN-LYR--DVMLE------NYKNLVAVDWES 121

  Fly   218 EIITV-TAPQVTTRKSAAKLLTQQENDKHQTPVGSKE--EARELEKEQVPQSAKRTSRRRGVVKQ 279
            .|.|. :|||....:.....:.:.|.:..     .:|  :..:.||.....|..:|.||....|:
Human   122 HINTKWSAPQQNFLQGKTSSVVEMERNHF-----GEELFDFNQCEKALSEHSCLKTHRRTYFRKK 181

  Fly   280 DVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSL 344
            ....   :..|.:.::..:.|..|            .|..|    .||. :|::|...|:....|
Human   182 TCEC---NQCEKAFRKPSIFTLHK------------KTDIG----EELP-NCNQCETAFSQHLHL 226

  Fly   345 M--------------IHRRQKGCINRNYKCNECEKVFVSPDHLAE------------HQA----- 378
            :              .|.::|     .|||::|||...|..||.|            |:.
Human   227 VCKKTSQNLHLVCKKTHTQEK-----PYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETF 286

  Fly   379 SHGA--------------HNCPECGIRCDSKEALSKHMVQGHKR--------------------- 408
            ||..              :.|..||........|::|: :.|.|
Human   287 SHSTALFVHMQTQDGEKFYECKACGKPFTESSYLTQHL-RTHSRVLPIEHKKFGKAFAFSPDLAK 350

  Fly   409 --NLRNQ-----CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETK 466
              .||.:     ||.|.|.||..|.|..|:|:||||||:.||.|||:||.::.|.:|:..|:..|
Human   351 HIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEK 415

  Fly   467 SFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS--------------------- 510
            .::|:.|..:|...:.||.|.|||||:||::|:.|...|..|.|
Human   416 PYECKECGKAFANSSHLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGK 480

  Fly   511 -------LAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQ 568
                   |.:|.|.|:.|||:.|:.|...|...:.|..|:|.|||||||.|..|.:.|:......
Human   481 AFIRSSFLIRHLRSHSAERPFECEECGKAFRYSSHLSQHKRIHTGERPYKCQKCGQAFSISSGLT 545

  Fly   569 MHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            :|.|||.|||.:.|..|.:.|.....:..||..|
Human   546 VHMRTHTGERPFECQECGKAFTRSTYLIRHLRSH 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/36 (17%)
		COG5048	<357..570	CDD:227381	90/299 (30%)
		C2H2 Zn finger	360..380	CDD:275368	9/36 (25%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	8/47 (17%)
		zf-H2C2_2	510..534	CDD:290200	10/51 (20%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630	16/89 (18%)
		KRAB	78..117	CDD:279668	16/88 (18%)
		C2H2 Zn finger	158..177	CDD:275368	6/18 (33%)
		C2H2 Zn finger	185..240	CDD:275368	11/74 (15%)
		COG5048	212..601	CDD:227381	109/374 (29%)
		C2H2 Zn finger	213..243	CDD:275368	4/29 (14%)
		C2H2 Zn finger	251..299	CDD:275368	11/47 (23%)
		C2H2 Zn finger	307..327	CDD:275368	5/20 (25%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		zf-H2C2_2	376..399	CDD:290200	14/22 (64%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	404..428	CDD:290200	7/23 (30%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..454	CDD:290200	12/22 (55%)
		zf-C2H2	445..467	CDD:278523	5/21 (24%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		zf-H2C2_2	488..512	CDD:290200	10/23 (43%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		zf-H2C2_2	515..539	CDD:290200	12/23 (52%)
		C2H2 Zn finger	531..551	CDD:275368	5/19 (26%)
		zf-H2C2_2	544..568	CDD:290200	10/23 (43%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910