DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF528

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	424	Identity:	133/424 - (31%)
Similarity:	191/424 - (45%)	Gaps:	70/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ENDKHQT----PVGSKEEARELEKE---------------------QVPQSAKRTSRRRGVVKQD 280
            ::|.|.|    |:...|.:.:|...                     |:.|:.::.|   |....:
Human   159 QHDTHNTLILLPMSESERSSKLGSNAGNKPCKNQLGFTFQLHLSDLQLFQAERKIS---GCKHFE 220

  Fly   281 VPATPPSDAEP------SPKQHRLGTQRKL--SAP------------RAGTVN--GPSTTSGAAT 323
            .|.:..|...|      |.|.|.|...|..  .||            :|...|  |....:.|:.
Human   221 KPVSDNSSVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAHIREKAYKCNEHGQVFRASASL 285

  Fly   324 TPEL------KYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHG 381
            |.::      .|.|..|...|:....|:|||| ..|  .:.|||:||.|:|.|..:|::||..|.
Human   286 TNQVIHNADNPYKCSECGKVFSCSSKLVIHRRMHTG--EKPYKCHECGKLFSSNSNLSQHQRIHT 348

  Fly   382 A---HNCPECG--IRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFV 441
            .   :.|.||.  .|..||.|..:.:..|.|   ..:|:.|.|||..::.|..|.:|||||||:.
Human   349 GEKPYKCHECDKVFRSSSKLAQHQRIHTGEK---PYKCHECDKVFNQIAHLVRHQKIHTGEKPYS 410

  Fly   442 CNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFT 506
            ||.|||.|::::.|.:|:..|:..|.:|||.|..:|..::.|.:|...|||.||::|:.|...|.
Human   411 CNKCGKVFSRHSYLAEHQTVHTGEKPYKCEECGKAFSVRSSLITHQLIHTGRKPYKCKECDKVFG 475

  Fly   507 TSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQ 571
            ..|.|..|:|.||.||||.|..|...|:..:.|..||:|||.|:||.|..|...|.:..|...|.
Human   476 RKCFLTSHQRIHTRERPYGCSQCGKIFSQKSDLIRHRKTHTDEKPYKCNKCGTAFREFSDLTAHF 540

  Fly   572 RTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQH 605
            ..|.||:.|.|..|.:.|:....:.||   |..|
Human   541 LIHSGEKPYECKECGKVFRYKSSLTSH---HRIH 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/23 (39%)
		COG5048	<357..570	CDD:227381	86/217 (40%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	7/22 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368	4/18 (22%)
		COG5048	277..712	CDD:227381	110/303 (36%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		zf-H2C2_2	312..336	CDD:290200	13/25 (52%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		zf-H2C2_2	339..364	CDD:290200	7/24 (29%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	368..392	CDD:290200	8/26 (31%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..420	CDD:290200	15/24 (63%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		zf-H2C2_2	423..447	CDD:290200	8/23 (35%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	535..560	CDD:290200	9/24 (38%)
		C2H2 Zn finger	551..571	CDD:275368	6/22 (27%)
		zf-H2C2_2	563..588	CDD:290200	4/12 (33%)
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	591..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	619..642	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
		zf-H2C2_2	675..700	CDD:290200
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000