DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6654 and ZNF282

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:XP_006716214.1 Gene:ZNF282 / 8427 HGNCID:13076 Length:672 Species:Homo sapiens


Alignment Length:540 Identity:130/540 - (24%)
Similarity:202/540 - (37%) Gaps:110/540 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 KCENSSRTLR-------QLLPNALPEEPDSKVSISCPVATTDQAV--------QTTSWEPDRCTA 117
            :.||....||       :|.|.:..|.|  ||    ||...|.||        ....|:.:....
Human   167 RLENLENLLRNRNFWVLRLPPGSKGEAP--KV----PVTFVDIAVYFSEDEWKNLDEWQKELYNN 225

  Fly   118 SVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELPDE---------------PVEKTTS 167
            .|:.:..|....:...|:.|....|..:...|..|::...|:|               |.:..:|
Human   226 LVKENYKTLMSLDAEGSVPKPDAPVQAEPREEPCVWEQRHPEEREIPMDPEAGAEPLVPAQDASS 290

  Fly   168 LI-----LQVQGNLKDEKEVVFTQTNVI---YEGDD--HELEQQIRECNLAIFEGVDNEAEIITV 222
            .:     |.|:|....|:..:.|::..:   ....|  ..::|:..:|   :::..| .|:....
Human   291 QVKREDTLCVRGQRGLEERAIPTESITVDSPISAQDLLSRIKQEEHQC---VWDQQD-LADRDIP 351

  Fly   223 TAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEA-RELEKEQVPQSAKRTSRRRGVVKQDVPATPP 286
            |.|...:..||..:|:..:.::...|.|.::.. .||..:..|..:..      :||...||.|.
Human   352 TDPNSESLISAHDILSWIKQEEQPYPWGPRDSMDGELGLDSGPSDSLL------MVKNPPPAPPQ 410

  Fly   287 SDAEPSPKQHRLGTQ-RKLSAPRAGTVNGP-------------STTSGAATTPELKYHCDRCNAG 337
            ...:|.|.|.:|.:| :..|.|.......|             ....|...:.|.....||...|
Human   411 PQPQPQPPQPQLQSQPQPQSLPPIAVAENPGGPPSRGLLDDGFQVLPGERGSGEAPPGGDRSTGG 475

  Fly   338 FAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA----HNCPECGIRCDSKEAL 398
            ...:........:.| ......|..|     .|..|......|||    ::|||||         
Human   476 GGGDGGGGGGGAEAG-TGAGGGCGSC-----CPGGLRRSLLLHGARSKPYSCPECG--------- 525

  Fly   399 SKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHS 463
                                |.|.:..:|..|.|.||.|:|:.|..|.|||..::.|.:|::.|.
Human   526 --------------------KSFGVRKSLIIHHRSHTKERPYECAECEKSFNCHSGLIRHQMTHR 570

  Fly   464 ETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDL 528
            ..:.:||..|..::..|..|.:|.|.|||::||:|.:|...|....:|.||:|.|||||||.|..
Human   571 GERPYKCSECEKTYSRKEHLQNHQRLHTGERPFQCALCGKSFIRKQNLLKHQRIHTGERPYTCGE 635

  Fly   529 CPMRFTALNVLKNHRRTHTG 548
            |...|.....||:|.|.|:|
Human   636 CGKSFRYKESLKDHLRVHSG 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 4/17 (24%)
C2H2 Zn finger 331..354 CDD:275368 4/22 (18%)
COG5048 <357..570 CDD:227381 64/196 (33%)
C2H2 Zn finger 360..380 CDD:275368 4/19 (21%)
C2H2 Zn finger 385..406 CDD:275370 5/20 (25%)
C2H2 Zn finger 414..434 CDD:275368 5/19 (26%)
zf-H2C2_2 427..451 CDD:290200 12/23 (52%)
C2H2 Zn finger 442..490 CDD:275368 15/47 (32%)
C2H2 Zn finger 470..487 CDD:275368 4/16 (25%)
zf-H2C2_2 482..507 CDD:290200 11/24 (46%)
C2H2 Zn finger 498..518 CDD:275368 7/19 (37%)
zf-H2C2_2 510..534 CDD:290200 13/23 (57%)
C2H2 Zn finger 526..546 CDD:275368 7/19 (37%)
zf-H2C2_2 539..563 CDD:290200 6/10 (60%)
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
ZNF282XP_006716214.1 KRAB 198..260 CDD:214630 11/61 (18%)
KRAB_A-box 198..237 CDD:143639 7/38 (18%)
COG5048 <507..652 CDD:227381 57/173 (33%)
zf-C2H2 519..541 CDD:278523 10/50 (20%)
C2H2 Zn finger 521..541 CDD:275368 10/48 (21%)
zf-H2C2_2 533..558 CDD:290200 12/24 (50%)
C2H2 Zn finger 549..569 CDD:275368 7/19 (37%)
zf-H2C2_2 562..586 CDD:290200 6/23 (26%)
zf-C2H2 575..597 CDD:278523 7/21 (33%)
C2H2 Zn finger 577..597 CDD:275368 6/19 (32%)
zf-H2C2_2 589..614 CDD:290200 11/24 (46%)
C2H2 Zn finger 605..625 CDD:275368 7/19 (37%)
zf-H2C2_2 617..642 CDD:290200 14/24 (58%)
C2H2 Zn finger 633..653 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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