DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF93

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	452	Identity:	139/452 - (30%)
Similarity:	202/452 - (44%)	Gaps:	62/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 NLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIIT-----VTAPQVTTRKSAA 234
            |:||..:.|..:.   ||...|...|.|:.|     |.|| |.::.|     :.....||:   :
Human    90 NIKDSFQKVILRR---YEKRGHGNLQLIKRC-----ESVD-ECKVHTGGYNGLNQCSTTTQ---S 142

  Fly   235 KLLTQQENDK--HQTPVGSKEEARELEKE--QVPQSAKRTSRRRGVV--KQDVPATPPSDAEPSP 293
            |:....:..|  |:....::...|..||:  :..:..|..::...::  |:......|...|...
Human   143 KVFQCDKYGKVFHKFSNSNRHNIRHTEKKPFKCIECGKAFNQFSTLITHKKIHTGEKPYICEECG 207

  Fly   294 KQHR----LGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSL----MIHRRQ 350
            |..:    |.|.:::.                  |.|..|.||:|:..|....:|    :||..:
Human   208 KAFKYSSALNTHKRIH------------------TGEKPYKCDKCDKAFIASSTLSKHEIIHTGK 254

  Fly   351 KGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKH--MVQGHKRNL 410
            |     .|||.||.|.|.....|.:|:..|..   :.|.|||...:....|:||  :..|.|..:
Human   255 K-----PYKCEECGKAFNQSSTLTKHKKIHTGEKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYV 314

  Fly   411 RNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPH 475
               |..|.|.|.....|..|.||||||||:.||.|||:|..::.|.:|:..|...|.:|||.|..
Human   315 ---CEECGKAFKYSRILTTHKRIHTGEKPYKCNKCGKAFIASSTLSRHEFIHMGKKHYKCEECGK 376

  Fly   476 SFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLK 540
            :|:..:.||.|.|.|||:||::||.|...|..|.:|:.|||.||||:||.|:.|...|.|.:.|.
Human   377 AFIWSSVLTRHKRVHTGEKPYKCEECGKAFKYSSTLSSHKRSHTGEKPYKCEECGKAFVASSTLS 441

  Fly   541 NHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            .|...|||::||.|..|.|.|.|......|::.|.||:.|.|..|.:.|.....:..|...|
Human   442 KHEIIHTGKKPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSSLTKHKKIH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/26 (31%)
		COG5048	<357..570	CDD:227381	88/217 (41%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/22 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368	2/19 (11%)
		COG5048	170..612	CDD:227381	117/360 (33%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		C2H2 Zn finger	203..223	CDD:275368	4/19 (21%)
		zf-H2C2_2	215..238	CDD:290200	8/40 (20%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		zf-H2C2_2	244..268	CDD:290200	11/28 (39%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..296	CDD:290200	7/23 (30%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..324	CDD:290200	9/26 (35%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..350	CDD:290200	15/21 (71%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		zf-H2C2_2	384..408	CDD:290200	13/23 (57%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		zf-H2C2_2	412..435	CDD:290200	12/22 (55%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	440..464	CDD:290200	11/23 (48%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..492	CDD:290200	8/24 (33%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		zf-H2C2_2	495..520	CDD:290200	2/9 (22%)
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	524..547	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		zf-H2C2_2	580..602	CDD:290200
		C2H2 Zn finger	595..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000