DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF436

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001070663.1	Gene:	ZNF436 / 80818	HGNCID:	20814	Length:	470	Species:	Homo sapiens

Alignment Length:	410	Identity:	133/410 - (32%)
Similarity:	202/410 - (49%)	Gaps:	61/410 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 QTPVGSKEEARELEKEQ-VPQSAKRTSRRRGVVKQD------VPATPPSDAEPSPKQH-----RL 298
            |.||..::.|..|.:|: .|..|.:....|.|::::      :.....|:.|.:|||.     :.
Human    11 QAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQF 75

  Fly   299 GTQRKLSAPRA--------GTVNGPSTTS--GAATTPE---------------------LKYH-C 331
            ||..:..|..|        |..:|..:..  |..|..|                     ::|| |
Human    76 GTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHIC 140

  Fly   332 DRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRC 392
            ..|...|:....|..|:: ..|  :|.|||.||.|.|....||.:||.:|..   ::|.|||
Human   141 SHCGKAFSQISDLNRHQKTHTG--DRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECG--- 200

  Fly   393 DSKEALSKHMVQG---HKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNAN 454
             .....|.|::|.   |.....::||.|.|.|..||.|..|.|.|:||||:.|..|||||:::::
Human   201 -KSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSH 264

  Fly   455 LRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHT 519
            |.||:..|:..|.::|..|...|..:::|..|.|.|||::|::|:.|...|:.:..|.:|:|.||
Human   265 LAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHT 329

  Fly   520 GERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPV 584
            ||:||.|:.|...|:.::.|..|:||||||:||.|..|.|:|::......||:.|.||:.|   .
Human   330 GEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPY---E 391

  Fly   585 CNEEFKSMPEMRSHLAGHEQ 604
            |||.::|..| ||.|..|::
Human   392 CNECWRSFGE-RSDLIKHQR 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/23 (26%)
		COG5048	<357..570	CDD:227381	85/218 (39%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	7/23 (30%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	8/19 (42%)
ZNF436	NP_001070663.1	KRAB	13..54	CDD:307490	9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..103		10/40 (25%)
		C2H2 Zn finger	140..160	CDD:275368	5/19 (26%)
		zf-H2C2_2	152..177	CDD:316026	11/26 (42%)
		C2H2 Zn finger	168..188	CDD:275368	9/19 (47%)
		zf-H2C2_2	180..205	CDD:316026	9/28 (32%)
		C2H2 Zn finger	196..216	CDD:275368	7/23 (30%)
		COG5048	<212..467	CDD:227381	81/203 (40%)
		C2H2 Zn finger	224..244	CDD:275368	10/19 (53%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	9/20 (45%)
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910