DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and Mynn

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_085034.2	Gene:	Mynn / 80732	MGIID:	1931415	Length:	610	Species:	Mus musculus

Alignment Length:	461	Identity:	140/461 - (30%)
Similarity:	210/461 - (45%)	Gaps:	84/461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 EVVFTQT------NV--IYEGDDH-ELEQQIRECNLAI----FEGVDNEAEIITVTAPQVTTRKS 232
            |.::|.|      ||  |::..|: ::|:.:.:|.:.:    |....:..||.::|. .:...:.
Mouse    78 EFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIASPSSTEISSITG-NIELNQQ 141

  Fly   233 AAKLLTQQENDKHQTPVG-----SKEEARELEKEQVPQSAKR----TSRRRGVVKQDVPATPPSD 288
            |..|..:..|::.::.|.     :..:.|.|.|:. .||.|:    :|::.|   |......|||
Mouse   142 ACLLTLRDYNNREKSEVSTDSVQANPKPRALTKKS-SQSKKKKKAFSSQKPG---QSKAVQYPSD 202

  Fly   289 AEPSPKQHRLGTQRKLSAP---------RAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSL 344
            ...|..........|||:|         .:..:...|.......|.::            |:...
Mouse   203 VLESASVELFLETSKLSSPVVEQIIQGNDSSELELTSVVENTFPTQDI------------VQTVT 255

  Fly   345 MIHRRQKGCINRNYKCNECEKVFVSPDH--LAEHQASHGA-----HNCPECGIRCDSKEALSKHM 402
            :..:|:|                 |..|  |.||..|:.|     :.....|...|::.:.:|.|
Mouse   256 VKRKRRK-----------------SQSHCALKEHSMSNIASVKSPYELENAGEELDARFSKAKPM 303

  Fly   403 VQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKS 467
                       ||.|.|||:..|:||.|||||.|.||:||::|||:|||...|:.|...|:..:.
Mouse   304 -----------CNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGERP 357

  Fly   468 FKCELCPHSFVTKAELTSHARTHTG-DKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPM 531
            :|||||...|..|.:|..|:|.|.| :||::|:||..:|.||.:|..|.|||:||:||.||.|..
Mouse   358 YKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQ 422

  Fly   532 RFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMR 596
            ||...:.|..|.|.||||:||||..|.|.|........|.|.|.||:.|||.:|.:.|.|..|:.
Mouse   423 RFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELN 487

  Fly   597 SHLAGH 602
            .|...|
Mouse   488 KHFRSH 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	3/22 (14%)
		COG5048	<357..570	CDD:227381	87/220 (40%)
		C2H2 Zn finger	360..380	CDD:275368	5/21 (24%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	12/19 (63%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	7/16 (44%)
		zf-H2C2_2	482..507	CDD:290200	11/25 (44%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
Mynn	NP_085034.2	BTB	14..115	CDD:279045	9/36 (25%)
		BTB	25..118	CDD:197585	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..199		10/46 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		5/16 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		1/4 (25%)
		C2H2 Zn finger	304..324	CDD:275368	12/19 (63%)
		zf-C2H2	304..324	CDD:278523	12/19 (63%)
		zf-H2C2_2	316..341	CDD:290200	16/24 (67%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	345..369	CDD:290200	9/23 (39%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	389..409	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..426	CDD:290200	14/24 (58%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		zf-H2C2_2	430..453	CDD:290200	13/22 (59%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..482	CDD:290200	10/24 (42%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		C2H2 Zn finger	501..522	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3920
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860