DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF696

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_112157.2	Gene:	ZNF696 / 79943	HGNCID:	25872	Length:	374	Species:	Homo sapiens

Alignment Length:	407	Identity:	117/407 - (28%)
Similarity:	169/407 - (41%)	Gaps:	85/407 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 PVGSKEEARELEKEQVPQS---AKRTSRRRGVVKQDVPATPPSDAE---PSPKQHRLGTQRKLSA 306
            |.|:||.:..:|.....::   |:..|..|....|...:|.|: ||   |..:.||.|..|.|.:
Human     7 PTGAKESSTLMESLAAVKAAFLAQAPSGSRSAEVQAAQSTEPA-AEAGAPEGEGHRGGPPRALGS 70

  Fly   307 ------------PRAGTVNGPSTT---------------------SGAATTPELKYHCDRCNAGF 338
                        | .|:..||.|:                     .|..:.....:.|..|...|
Human    71 LGLCENQEARERP-GGSPRGPVTSEKTGGQSGLESDVPPNAGPGAEGGGSWKGRPFPCGACGRSF 134

  Fly   339 AVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALS 399
            ........||. ..|  .:.|:|::|.|.|:...|:..||.:|..   :.|.|||
Human   135 KCSSDAAKHRSIHSG--EKPYECSDCGKAFIHSSHVVRHQRAHSGERPYACAECG---------- 187

  Fly   400 KHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSE 464
                               |.|.....|..|.|:||||||:.|..|||:|.|.::..:|:..|:.
Human   188 -------------------KAFGQSFNLLRHQRVHTGEKPYACADCGKAFGQRSDAAKHRRTHTG 233

  Fly   465 TKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLC 529
            .:.:.|..|...|:..:.:..|.|||.|:.|:||..|...|:.|.:|.:|:|.||||||:||..|
Human   234 ERLYACGECGKRFLHSSNVVRHRRTHHGENPYECRECGQAFSQSSNLLQHQRVHTGERPFACQDC 298

  Fly   530 PMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPE 594
            ...|:..:.|:.|||.||||:|:.|..|.:.|........|||.|.||:.:.|..|...|:
Human   299 GRAFSRSSFLREHRRIHTGEKPHQCGHCGRAFRALSGFFRHQRLHTGEKPFRCTECGRAFR---- 359

  Fly   595 MRSHLAGHEQHDKRLVH 611
            :..||..|     |.||
Human   360 LSFHLIQH-----RRVH 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/23 (26%)
		COG5048	<357..570	CDD:227381	71/215 (33%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	13/47 (28%)
		C2H2 Zn finger	470..487	CDD:275368	3/16 (19%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF696	NP_112157.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..119		19/90 (21%)
		COG5048	<124..340	CDD:227381	77/246 (31%)
		C2H2 Zn finger	127..147	CDD:275368	5/19 (26%)
		zf-H2C2_2	142..162	CDD:290200	7/21 (33%)
		C2H2 Zn finger	155..175	CDD:275368	7/19 (37%)
		zf-H2C2_2	167..190	CDD:290200	9/51 (18%)
		C2H2 Zn finger	183..203	CDD:275368	9/48 (19%)
		zf-H2C2_2	195..218	CDD:290200	13/22 (59%)
		C2H2 Zn finger	211..231	CDD:275368	7/19 (37%)
		zf-H2C2_2	226..248	CDD:290200	5/21 (24%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		zf-H2C2_2	251..276	CDD:290200	10/24 (42%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		zf-H2C2_2	279..304	CDD:290200	13/24 (54%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..330	CDD:290200	11/21 (52%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	338..358	CDD:290200	8/19 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000