DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF668

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001166140.1	Gene:	ZNF668 / 79759	HGNCID:	25821	Length:	642	Species:	Homo sapiens

Alignment Length:	370	Identity:	114/370 - (30%)
Similarity:	169/370 - (45%)	Gaps:	50/370 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 VKQDVPATPPSDAE------PSPKQHRLGTQRKL--------SAPRA---GTVNGPSTTSGAAT- 323
            |.::.|.|...:.|      |:|...|.|.:.|.        :||||   ...:||:..|....
Human    14 VPRETPFTKAMEVEAAEARSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGPADCSEEVAE 78

  Fly   324 ---TPELKYHCDRCN----AGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHG 381
               .||.:...:..:    :|.|.:.             |.|.|..|.|.:.:...|..|..||.
Human    79 VKPKPETEAKAEEASGEKVSGSAAKP-------------RPYACPLCPKAYKTAPELRSHGRSHT 130

  Fly   382 AHN---CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCN 443
            ...   |||||.|......|..|:. .|...|..:|..|.|.:..||.|:.|.|.||||:|:.|.
Human   131 GEKPFPCPECGRRFMQPVCLRVHLA-SHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACA 194

  Fly   444 ICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
            .|||||...:..|:|:..|:..:.:.||.|..::....:|.:|.|:|||::||.|..|...|:.|
Human   195 DCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRS 259

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            .||..|:|.|..::||.|..|...||.|:..::|.|||:||:|::||.|.:.|:.....:.|||.
Human   260 SSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRA 324

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGHE--------QHDKRLV 610
            |:|.:.|.|..|.::|:...::..|...|.        |.||..|
Human   325 HEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFV 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	2/26 (8%)
		COG5048	<357..570	CDD:227381	78/215 (36%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF668	NP_001166140.1	COG5048	103..437	CDD:227381	94/281 (33%)
		C2H2 Zn finger	109..129	CDD:275370	5/19 (26%)
		zf-H2C2_2	121..144	CDD:290200	9/22 (41%)
		C2H2 Zn finger	137..157	CDD:275368	8/20 (40%)
		C2H2 Zn finger	165..185	CDD:275368	8/19 (42%)
		zf-H2C2_2	178..201	CDD:290200	13/22 (59%)
		C2H2 Zn finger	193..213	CDD:275368	8/19 (42%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		zf-H2C2_2	233..258	CDD:290200	11/24 (46%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		COG5048	271..618	CDD:227381	33/99 (33%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		zf-H2C2_2	289..313	CDD:290200	10/23 (43%)
		C2H2 Zn finger	305..325	CDD:275368	7/19 (37%)
		zf-H2C2_2	317..342	CDD:290200	9/24 (38%)
		C2H2 Zn finger	333..353	CDD:275368	4/19 (21%)
		zf-H2C2_2	345..369	CDD:290200	5/23 (22%)
		C2H2 Zn finger	361..381	CDD:275368	4/9 (44%)
		zf-H2C2_2	373..397	CDD:290200
		C2H2 Zn finger	389..409	CDD:275368
		zf-H2C2_2	401..425	CDD:290200
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		zf-H2C2_2	554..577	CDD:290200
		C2H2 Zn finger	569..589	CDD:275368
		zf-H2C2_2	582..606	CDD:290200
		C2H2 Zn finger	597..617	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910