DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF329

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_011525612.1	Gene:	ZNF329 / 79673	HGNCID:	14209	Length:	564	Species:	Homo sapiens

Alignment Length:	607	Identity:	166/607 - (27%)
Similarity:	241/607 - (39%)	Gaps:	151/607 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 IREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLLPNALP-EEPDSKVSISC 96
            :..||:..|             |||.:.:.:    .|||....|||   :||. |:|.::.:| |
Human    44 VERFTREVP-------------CLSSLGDGW----DCENQEGHLRQ---SALTLEKPGTQEAI-C 87

  Fly    97 P--------VATTD----QAVQTTS--WEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYE 147
            .        :|::|    |.|..|:  ..||...:.:..|..
Human    88 EYPGFGEHLIASSDLPPSQRVLATNGFHAPDSNVSGLDCDPA----------------------- 129

  Fly   148 GEGEVFDYELPDEP---VEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAI 209
                     ||..|   .:|.|                          ||..           |.
Human   130 ---------LPSYPKSYADKRT--------------------------GDSD-----------AC 148

  Fly   210 FEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKE---------EARELEKEQVPQ 265
            .:|.::..|:|....|   .|:...|.....::..|.|.:|.::         |.:..|......
Human   149 GKGFNHSMEVIHGRNP---VREKPYKYPESVKSFNHFTSLGHQKIMKRGKKSYEGKNFENIFTLS 210

  Fly   266 SAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYH 330
            |:...::|.               .|..||:|.....|.....:..|....|.:|     |..|.
Human   211 SSLNENQRN---------------LPGEKQYRCTECGKCFKRNSSLVLHHRTHTG-----EKPYT 255

  Fly   331 CDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIR 391
            |:.|...|:...:|::|:| ..|  .:.|:|::|.|.|.....|.:||..|..   :.|.|||..
Human   256 CNECGKSFSKNYNLIVHQRIHTG--EKPYECSKCGKAFSDGSALTQHQRIHTGEKPYECLECGKT 318

  Fly   392 CDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLR 456
            .:...:|..|. :.|......:||.|.|.||.:|.|..|:||||||||:.|:.|||:|...:.|.
Human   319 FNRNSSLILHQ-RTHTGEKPYRCNECGKPFTDISHLTVHLRIHTGEKPYECSKCGKAFRDGSYLT 382

  Fly   457 QHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGE 521
            ||:..|:..|.|:|..|..||...:.|..|.:.|:|:||:||:.|...|..|..|.:|:|.||||
Human   383 QHERTHTGEKPFECAECGKSFNRNSHLIVHQKIHSGEKPYECKECGKTFIESAYLIRHQRIHTGE 447

  Fly   522 RPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCN 586
            :||.|:.|...|..:..|..|:||||||:||.|..|.|.|........|||.|..|..|.||.|.
Human   448 KPYGCNQCQKLFRNIAGLIRHQRTHTGEKPYECNQCGKAFRDSSCLTKHQRIHTKETPYQCPECG 512

  Fly   587 EEFKSMPEMRSHLAGHEQHDKR 608
            :.||    ..||||.|::...|
Human   513 KSFK----QNSHLAVHQRLHSR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	11/45 (24%)
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	85/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	9/19 (47%)
ZNF329	XP_011525612.1	COG5048	200..562	CDD:227381	122/358 (34%)
		zf-C2H2	226..248	CDD:278523	3/21 (14%)
		C2H2 Zn finger	228..248	CDD:275368	2/19 (11%)
		zf-H2C2_2	240..264	CDD:290200	7/28 (25%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..292	CDD:290200	8/25 (32%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	8/24 (33%)
		C2H2 Zn finger	312..332	CDD:275368	6/20 (30%)
		zf-H2C2_2	324..348	CDD:290200	7/24 (29%)
		C2H2 Zn finger	340..360	CDD:275368	10/19 (53%)
		zf-H2C2_2	352..375	CDD:290200	14/22 (64%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		zf-H2C2_2	380..405	CDD:290200	10/24 (42%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		zf-H2C2_2	408..431	CDD:290200	9/22 (41%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..487	CDD:290200	13/21 (62%)
		DUF45	<480..547	CDD:302795	21/55 (38%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..517	CDD:290200	11/27 (41%)
		C2H2 Zn finger	508..528	CDD:275368	10/23 (43%)
		C2H2 Zn finger	536..556	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910