DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF236

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001293018.1	Gene:	ZNF236 / 7776	HGNCID:	13028	Length:	1847	Species:	Homo sapiens

Alignment Length:	757	Identity:	163/757 - (21%)
Similarity:	266/757 - (35%)	Gaps:	233/757 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KPRRNDNLPEKVCLSCLSEISNCYTFKI-------KCENS-------------SRTLRQLLPNAL 84
            ||.|.|..|:              ||.:       ||.:|             ||.........|
Human    66 KPHRCDQCPQ--------------TFNVEFNLTLHKCTHSGEDPTCPVCNKKFSRVASLKAHIML 116

  Fly    85 PEEPDSKVSISCPVATTDQAVQTTSWEPDR----------CTASVQTDAVTTTDAEQNTSL---- 135
            .|:.::.:...|....|.|:......|..|          |.| .:.:..|:::.:::...
Human   117 HEKEENLICSECGDEFTLQSQLAVHMEEHRQELAGTRQHACKA-CKKEFETSSELKEHMKTHYKI 180

  Fly   136 -IKSTISVDLDYEGEGEVFDYELP--DEPVEKTTSLILQVQ-------------GNLKDEKEVVF 184
             :.||.|.:.:.:..|  |.|..|  .:..:|.:.|...::             |...::|..:
Human   181 RVSSTRSYNRNIDRSG--FTYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQKGAL- 242

  Fly   185 TQTNVI------------------YEGDDHELEQQIR------------ECNLAIFE---GVDNE 216
             ||::|                  .:|:.....|::.            ||: .:|:   .::..
Human   243 -QTHMIKHTGEKPHACAFCPAAFSQKGNLQSHVQRVHSEVKNGPTYNCTECS-CVFKSLGSLNTH 305

  Fly   217 AEIITVTAPQVTTRKS-AAKLLTQ--------QENDKHQTPVGSK----------------EEAR 256
            ...:.:..||.:|..: .|.:||.        |:.:...|...|:                .|..
Human   306 ISKMHMGGPQNSTSSTETAHVLTATLFQTLPLQQTEAQATSASSQPSSQAVSDVIQQLLELSEPA 370

  Fly   257 ELEKEQVPQSAKRTSRRRGVVKQDV---------PATPPSDAEPSPKQHRLGTQRKLSAPRAGTV 312
            .:|..|.||..::.|...| :.||:         .::.|:.|.|:...|     .|.|||.|
Human   371 PVESGQSPQPGQQLSITVG-INQDILQQALENSGLSSIPAAAHPNDSCH-----AKTSAPHA--- 426

  Fly   313 NGP--STTSGAATTP---------ELKYHCDRCNAGFAVEKSLMIH---RRQKGCINRNYKCNEC 363
            ..|  |:.|...|.|         |.....|:.......:||..:.   |.:.|.  |.:.|..|
Human   427 QNPDVSSVSNEQTDPTDAEQEKEQESPEKLDKKEKKMIKKKSPFLPGSIREENGV--RWHVCPYC 489

  Fly   364 EKVFVSPDHLAEHQASHGAH----NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTML 424
            .|.|..|..|..|...| .|    .||:|......|..|:.| ::.|......:|..|.|.|:..
Human   490 AKEFRKPSDLVRHIRIH-THEKPFKCPQCFRAFAVKSTLTAH-IKTHTGIKAFKCQYCMKSFSTS 552

  Fly   425 STLRDHMRIHTGEKPFVCNICGKSFTQNANLRQH---KLRHSETKSFKCELCP------------ 474
            .:|:.|:|:|||.:||.|..|.|.|..:.:.:.|   ..:|:|.:..:.:..|
Human   553 GSLKVHIRLHTGVRPFACPHCDKKFRTSGHRKTHIASHFKHTELRKMRHQRKPAKVRVGKTNIPV 617

  Fly   475 -------------------------------HSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
                                           ::||.:|           |:|::|..|...:..|
Human   618 PDIPLQEPILITDLGLIQPIPKNQFFQSYFNNNFVNEA-----------DRPYKCFYCHRAYKKS 671

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            |.|.:|.|.||||:|:.|..|...|.:..|||.|.|||||.:.:.|..|:..||..|..:.|...
Human   672 CHLKQHIRSHTGEKPFKCSQCGRGFVSAGVLKAHIRTHTGLKSFKCLICNGAFTTGGSLRRHMGI 736

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGH--------EQHDK 607
            |...|.|:||.|.:.||:....:.|:..|        :||.:
Human   737 HNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQQ 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	12/58 (21%)
		C2H2 Zn finger	331..354	CDD:275368	5/25 (20%)
		COG5048	<357..570	CDD:227381	70/262 (27%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	11/93 (12%)
		C2H2 Zn finger	470..487	CDD:275368	4/59 (7%)
		zf-H2C2_2	482..507	CDD:290200	4/24 (17%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF236	NP_001293018.1	C2H2 Zn finger	41..61	CDD:275368
		COG5048	<52..234	CDD:227381	31/184 (17%)
		C2H2 Zn finger	70..90	CDD:275368	6/33 (18%)
		C2H2 Zn finger	97..117	CDD:275368	2/19 (11%)
		C2H2 Zn finger	125..145	CDD:275370	4/19 (21%)
		C2H2 Zn finger	157..177	CDD:275368	3/20 (15%)
		COG5048	197..707	CDD:227381	114/536 (21%)
		zf-C2H2	199..221	CDD:278523	4/21 (19%)
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		zf-H2C2_2	214..238	CDD:290200	2/23 (9%)
		C2H2 Zn finger	229..249	CDD:275368	5/21 (24%)
		zf-H2C2_2	241..266	CDD:290200	3/26 (12%)
		C2H2 Zn finger	257..278	CDD:275368	2/20 (10%)
		C2H2 Zn finger	289..310	CDD:275368	3/21 (14%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		zf-H2C2_2	498..522	CDD:290200	7/24 (29%)
		C2H2 Zn finger	514..534	CDD:275368	6/20 (30%)
		zf-H2C2_2	527..551	CDD:290200	7/24 (29%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		zf-H2C2_2	554..579	CDD:290200	12/24 (50%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		COG5048	653..1057	CDD:227381	45/137 (33%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		zf-H2C2_2	673..698	CDD:290200	11/24 (46%)
		C2H2 Zn finger	689..709	CDD:275368	8/19 (42%)
		C2H2 Zn finger	717..737	CDD:275368	6/19 (32%)
		zf-H2C2_2	729..754	CDD:290200	8/24 (33%)
		C2H2 Zn finger	745..765	CDD:275368	6/19 (32%)
		COG5048	953..1315	CDD:227381
		zf-C2H2	969..991	CDD:278523
		C2H2 Zn finger	971..991	CDD:275368
		zf-H2C2_2	983..1008	CDD:290200
		C2H2 Zn finger	999..1019	CDD:275368
		C2H2 Zn finger	1027..1047	CDD:275368
		zf-H2C2_2	1039..1064	CDD:290200
		C2H2 Zn finger	1171..1191	CDD:275368
		zf-H2C2_2	1183..1207	CDD:290200
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		zf-H2C2_2	1239..1264	CDD:290200
		C2H2 Zn finger	1255..1275	CDD:275370
		C2H2 Zn finger	1661..1682	CDD:275368
		C2H2 Zn finger	1690..1710	CDD:275368
		COG5048	1707..>1775	CDD:227381
		C2H2 Zn finger	1726..1746	CDD:275368
		zf-H2C2_2	1739..1763	CDD:290200
		C2H2 Zn finger	1754..1774	CDD:275368
		zf-H2C2_2	1766..1791	CDD:290200
		C2H2 Zn finger	1782..1800	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910