DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF189

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens

Alignment Length:	605	Identity:	165/605 - (27%)
Similarity:	243/605 - (40%)	Gaps:	111/605 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RQLLPNALPEEPDSKVSISCPVATTDQAVQ-TTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTI 140
            |.|..:.:.|...:.||:.  |...|:..: |...|.:.....|:...|..|       .|||.|
Human    36 RSLYKDVMMENYGNLVSLD--VLNRDKDEEPTVKQEIEEIEEEVEPQGVIVT-------RIKSEI 91

  Fly   141 SVD------------LDYEGEGEVFDYELPDEPVEKTTSL------ILQVQGNLKDE-------- 179
            ..|            ||.: .| :|.:|:|.|.:.:...:      |::.:.|.:::
Human    92 DQDPMGRETFELVGRLDKQ-RG-IFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECG 154

  Fly   180 ----KEVVFTQTNVIYEGDDHELEQQIRECNLAIFEG--VDNEAEIITVTAPQV-----TTRKSA 233
                ::..|.|...::.|   |...|..||..:....  |.....|.|...|..     .|...:
Human   155 KGFVRKAHFIQHQRVHTG---EKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVS 216

  Fly   234 AKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRL 298
            :.|:..|.....:.|.            |..|..:..|:||.:||.....|       ..|.|:.
Human   217 STLIRHQRIHTGERPY------------QCNQCKQSFSQRRSLVKHQRIHT-------GEKPHKC 262

  Fly   299 GTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNE 362
            ....|..:.::..:....|.:|     |..|||.:|...|:....|:.|:| ..|  .|.:||.|
Human   263 SDCGKAFSWKSHLIEHQRTHTG-----EKPYHCTKCKKSFSRNSLLVEHQRIHTG--ERPHKCGE 320

  Fly   363 CEKVFVSPDHLAEHQASHGAHN---CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTML 424
            |.|.|....:|.:||..|....   |.|||........|.:|. :.|......||..|.|.|:.|
Human   321 CGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQ-RIHTGERPYQCKECGKSFSQL 384

  Fly   425 STLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRH--------SET---------------- 465
            ..|..|.|||||:||..|..|||:|::::.|.||:..|        :||
Human   385 CNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEV 449

  Fly   466 ----KSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYAC 526
                ||:||:.|..:|...|.|..|.|.|||:||:.|.||...|:.|..|.:|:|.|||||||.|
Human   450 YPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLC 514

  Fly   527 DLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKS 591
            ..|...|:.|..|..|:..|||.:|:.|..|.|.|::......|||.|.||:.|.|..|::.|..
Human   515 RQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQ 579

  Fly   592 MPEMRSHLAGHEQHDKRLVH 611
            ...:.:|...|.:...:..|
Human   580 QRSLVNHQKIHAEVKTQETH 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	1/1 (100%)
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	87/243 (36%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	21/75 (28%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	10/23 (43%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083	5/17 (29%)
		COG5048	138..524	CDD:227381	116/415 (28%)
		C2H2 Zn finger	150..170	CDD:275368	2/19 (11%)
		C2H2 Zn finger	178..198	CDD:275368	3/19 (16%)
		C2H2 Zn finger	206..226	CDD:275368	3/19 (16%)
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	1/19 (5%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	6/20 (30%)
		C2H2 Zn finger	374..394	CDD:275368	8/19 (42%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		C2H2 Zn finger	458..478	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		C2H2 Zn finger	514..534	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..551	CDD:404364	10/24 (42%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..579	CDD:404364	10/23 (43%)
		C2H2 Zn finger	570..590	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910