DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF157

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_003437.2	Gene:	ZNF157 / 7712	HGNCID:	12942	Length:	506	Species:	Homo sapiens

Alignment Length:	551	Identity:	153/551 - (27%)
Similarity:	215/551 - (39%)	Gaps:	87/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQT---DAVTTTD---AEQNT 133
            |..|..|..:|.||..  |....|:..|.||..|..|..|...:.:|   |.:..|.   |....
Human     6 TSPQRFPALIPGEPGR--SFEGSVSFEDVAVDFTRQEWHRLDPAQRTMHKDVMLETYSNLASVGL 68

  Fly   134 SLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLI----------LQVQGNLKDEKEVVFTQTN 188
            .:.|..:...|:...|..:.:.|........:.||:          |:...:|...:::.....|
Human    69 CVAKPEMIFKLERGEELWILEEESSGHGYSGSLSLLCGNGSVGDNALRHDNDLLHHQKIQTLDQN 133

  Fly   189 VIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKE 253
            |.|.|           |..|..|...            ...||              :||.|.|.
Human   134 VEYNG-----------CRKAFHEKTG------------FVRRK--------------RTPRGDKN 161

  Fly   254 -EARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPST 317
             |..|        ..|...|:..:|:.       .......:.:..|...|..:.|:..:....|
Human   162 FECHE--------CGKAYCRKSNLVEH-------LRIHTGERPYECGECAKTFSARSYLIAHQKT 211

  Fly   318 TSGAATTPELKYHCDRCNAGFAVEKSLMIH-RRQKGCINRNYKCNECEKVFVSPDHLAEHQASHG 381
            .:|     |..:.|:.|...|..:..|::| |...|  .|.|:|.||.|.|.....|..||.:|.
Human   212 HTG-----ERPFECNECGKSFGRKSQLILHTRTHTG--ERPYECTECGKTFSEKATLTIHQRTHT 269

  Fly   382 A---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCN 443
            .   :.|.|||.....|.:|::|. :.|......:|..|.|.|....:|..|.||||||||:.|.
Human   270 GEKPYECSECGKTFRVKISLTQHH-RTHTGEKPYECGECGKNFRAKKSLNQHQRIHTGEKPYECG 333

  Fly   444 ICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
            .|||.|.....|..|:..|:..|.::|..|..||...:.|..|.|.|||:||:||..|...|...
Human   334 ECGKFFRMKMTLNNHQRTHTGEKPYQCNECGKSFRVHSSLGIHQRIHTGEKPYECNECGNAFYVK 398

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            ..|.:|:|.|:||:||.|..|...|:....|..||||||||:||.|..|...|..:.....|||.
Human   399 ARLIEHQRMHSGEKPYECSECGKIFSMKKSLCQHRRTHTGEKPYECSECGNAFYVKVRLIEHQRI 463

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGHEQ 604
            |.|||.:.|..|.:.|.    .::||..|::
Human   464 HTGERPFECQECGKAFC----RKAHLTEHQR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	1/3 (33%)
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	82/215 (38%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF157	NP_003437.2	KRAB	27..87	CDD:214630	14/59 (24%)
		KRAB	27..66	CDD:279668	11/38 (29%)
		C2H2 Zn finger	137..156	CDD:275368	6/55 (11%)
		COG5048	159..499	CDD:227381	115/359 (32%)
		C2H2 Zn finger	164..184	CDD:275368	4/34 (12%)
		zf-H2C2_2	176..200	CDD:290200	3/30 (10%)
		C2H2 Zn finger	192..212	CDD:275368	3/19 (16%)
		zf-H2C2_2	204..229	CDD:290200	6/29 (21%)
		C2H2 Zn finger	220..240	CDD:275368	6/19 (32%)
		zf-H2C2_2	236..256	CDD:290200	9/21 (43%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		zf-H2C2_2	261..283	CDD:290200	8/21 (38%)
		C2H2 Zn finger	276..296	CDD:275368	7/20 (35%)
		zf-H2C2_2	288..311	CDD:290200	6/23 (26%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		zf-H2C2_2	316..339	CDD:290200	14/22 (64%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	6/21 (29%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	372..395	CDD:290200	11/22 (50%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..424	CDD:290200	10/22 (45%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..451	CDD:290200	12/19 (63%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..479	CDD:290200	9/21 (43%)
		zf-C2H2	470..492	CDD:278523	6/25 (24%)
		C2H2 Zn finger	472..492	CDD:275368	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910