DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF135

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_009065.1	Gene:	ZNF135 / 7694	HGNCID:	12919	Length:	682	Species:	Homo sapiens

Alignment Length:	329	Identity:	117/329 - (35%)
Similarity:	163/329 - (49%)	Gaps:	20/329 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 DVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSL 344
            |:|..|.:....||  |..||:.|...|....:.       .....|..|.|..|...|:...:|
Human   198 DLPHQPMTPERQSP--HTWGTRGKREKPDLNVLQ-------KTCVKEKPYKCQECGKAFSHSSAL 253

  Fly   345 MIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQG 405
            :.|.| ..|  .|.|:|:||.|.|.:...|.:||..|..   :.|.:||...:....|.:|. :.
Human   254 IEHHRTHTG--ERPYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQ-RT 315

  Fly   406 HKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKC 470
            |......:|:.|.|.|:..|:...|.|.||||||:.|:.|||:|.|:.:|.||...|:..|.::|
Human   316 HTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFRQSIHLTQHLRIHTGEKPYQC 380

  Fly   471 ELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTA 535
            ..|..:|...:.||.|.|.|||:||:||..|...||....|.:|:|.||||:||.|..|...|:.
Human   381 GECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFSQ 445

  Fly   536 LNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLA 600
            ..:|..|||.||||:||.|..|.|||:.......|:|||.||:.|.|..|.:.|:    ..:||.
Human   446 STLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFR----QSTHLT 506

  Fly   601 GHEQ 604
            .|::
Human   507 QHQR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	84/215 (39%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF135	NP_009065.1	KRAB	26..85	CDD:214630
		KRAB	26..65	CDD:279668
		zf-C2H2	238..260	CDD:278523	7/21 (33%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		COG5048	264..665	CDD:227381	98/252 (39%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		zf-H2C2_2	280..305	CDD:290200	7/24 (29%)
		C2H2 Zn finger	296..316	CDD:275368	5/20 (25%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..361	CDD:290200	13/21 (62%)
		C2H2 Zn finger	352..372	CDD:275368	9/19 (47%)
		zf-H2C2_2	364..389	CDD:290200	8/24 (33%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-H2C2_2	392..417	CDD:290200	13/24 (54%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		zf-H2C2_2	421..445	CDD:290200	12/23 (52%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..501	CDD:290200	10/28 (36%)
		C2H2 Zn finger	492..512	CDD:275368	6/23 (26%)
		zf-H2C2_2	504..529	CDD:290200	3/7 (43%)
		C2H2 Zn finger	520..540	CDD:275368
		zf-H2C2_2	532..557	CDD:290200
		C2H2 Zn finger	548..568	CDD:275368
		zf-H2C2_2	561..585	CDD:290200
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		zf-H2C2_2	619..641	CDD:290200
		C2H2 Zn finger	632..652	CDD:275368
		zf-H2C2_2	644..669	CDD:290200
		C2H2 Zn finger	660..680	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910