DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6654 and ZNF132

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_003424.3 Gene:ZNF132 / 7691 HGNCID:12916 Length:706 Species:Homo sapiens


Alignment Length:650 Identity:161/650 - (24%)
Similarity:235/650 - (36%) Gaps:200/650 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 DGGS---GSC-LADMIREFTKTKPRRN-DNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLLP 81
            :||.   ||| |..:....:..||..| ..|||......|.|.|||....:|...        ||
Human   196 EGGKVILGSCDLLQLQAVDSGQKPYSNLGQLPEVCTTQKLFECSNCGKAFLKSST--------LP 252

  Fly    82 NALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDY 146
            |.|....: ::..:||..                                               
Human   253 NHLRTHSE-EIPFTCPTG----------------------------------------------- 269

  Fly   147 EGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFE 211
                                       ||..:||.::..:.  .:.|   |:....:||..|.  
Human   270 ---------------------------GNFLEEKSILGNKK--FHTG---EIPHVCKECGKAF-- 300

  Fly   212 GVDNEAEIITVTAPQVTTRKSAAKLLTQQE-----------------NDK----HQTPVGSKEEA 255
                               ..::||...|:                 |.|    |...:.|.|..
Human   301 -------------------SHSSKLRKHQKFHTEVKYYECIACGKTFNHKLTFVHHQRIHSGERP 346

  Fly   256 RELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTT-- 318
            .|.:     :..|..|.|..:::.:             |.|.  .:|.....:.|.....|:.  
Human   347 YECD-----ECGKAFSNRSHLIRHE-------------KVHT--GERPFECLKCGRAFSQSSNFL 391

  Fly   319 -SGAATTPELKYHCDRCNAGFAVEKSLMIH-RRQKGCINRNYKCNECEKVFVSPDHLAEHQASHG 381
             .....|....|.|.:|...|:...:|:.| |...|  .|.|:|:||.:.|.:..:||:||..|.
Human   392 RHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTG--ERPYECSECGRAFNNNSNLAQHQKVHT 454

  Fly   382 AH---NCPECG---------IR-------------CDSKEALSKH--MVQGHKRNLRN---QCNI 416
            ..   .|.|||         :|             ||..:|.|..  ::|..|.:...   :|:.
Human   455 GERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVHTGQRPYECSE 519

  Fly   417 CQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKA 481
            |:|.|:..|:|..|.||||||||:.|:.|||:|..::.|.:|...|::.:.::|..|...|...:
Human   520 CRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHTKERPYECNECGKFFSQNS 584

  Fly   482 ELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTH 546
            .|..|.:.|||:||::|..|...|:...||..|.|.|||||||.|..|...|::.:.|..|:|.|
Human   585 ILIKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGERPYECSECGRAFSSNSHLVRHQRVH 649

  Fly   547 TGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLVH 611
            |.||||.|..|.|.|::|.....||:.|..||.|.|..|.:.|       |||....||.|  :|
Human   650 TQERPYECIQCGKAFSERSTLVRHQKVHTRERTYECSQCGKLF-------SHLCNLAQHKK--IH 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 18/61 (30%)
C2H2 Zn finger 331..354 CDD:275368 7/23 (30%)
COG5048 <357..570 CDD:227381 85/242 (35%)
C2H2 Zn finger 360..380 CDD:275368 8/19 (42%)
C2H2 Zn finger 385..406 CDD:275370 10/44 (23%)
C2H2 Zn finger 414..434 CDD:275368 8/19 (42%)
zf-H2C2_2 427..451 CDD:290200 15/23 (65%)
C2H2 Zn finger 442..490 CDD:275368 13/47 (28%)
C2H2 Zn finger 470..487 CDD:275368 4/16 (25%)
zf-H2C2_2 482..507 CDD:290200 10/24 (42%)
C2H2 Zn finger 498..518 CDD:275368 7/19 (37%)
zf-H2C2_2 510..534 CDD:290200 13/23 (57%)
C2H2 Zn finger 526..546 CDD:275368 6/19 (32%)
zf-H2C2_2 539..563 CDD:290200 13/23 (57%)
C2H2 Zn finger 554..574 CDD:275368 7/19 (37%)
C2H2 Zn finger 582..602 CDD:275368 6/19 (32%)
ZNF132NP_003424.3 KRAB 37..78 CDD:307490
COG5048 105..528 CDD:227381 85/462 (18%)
C2H2 Zn finger 116..136 CDD:275368
C2H2 Zn finger 144..164 CDD:275368
C2H2 Zn finger 238..285 CDD:275368 14/131 (11%)
C2H2 Zn finger 293..313 CDD:275368 6/40 (15%)
C2H2 Zn finger 321..341 CDD:275368 3/19 (16%)
C2H2 Zn finger 349..369 CDD:275368 4/37 (11%)
C2H2 Zn finger 377..397 CDD:275368 2/19 (11%)
COG5048 383..>706 CDD:227381 111/333 (33%)
C2H2 Zn finger 405..425 CDD:275368 6/19 (32%)
C2H2 Zn finger 433..453 CDD:275368 8/19 (42%)
C2H2 Zn finger 461..481 CDD:275368 5/19 (26%)
C2H2 Zn finger 489..509 CDD:275368 6/19 (32%)
C2H2 Zn finger 517..537 CDD:275368 8/19 (42%)
C2H2 Zn finger 545..565 CDD:275368 7/19 (37%)
C2H2 Zn finger 573..593 CDD:275368 5/19 (26%)
C2H2 Zn finger 601..621 CDD:275368 7/19 (37%)
C2H2 Zn finger 629..649 CDD:275368 6/19 (32%)
C2H2 Zn finger 657..677 CDD:275368 7/19 (37%)
C2H2 Zn finger 685..705 CDD:275368 9/28 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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