DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zfp998

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001277125.1	Gene:	Zfp998 / 76803	MGIID:	1924053	Length:	464	Species:	Mus musculus

Alignment Length:	494	Identity:	148/494 - (29%)
Similarity:	208/494 - (42%)	Gaps:	86/494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 SLILQVQGNL-KDEK-EVVFTQTNVIYEGDDHELEQ------------------QIRECNLAIFE 211
            :|:...|.|| ||.. |..:..|::.|:.:||.:|:                  ::.|||
Mouse    19 NLLEPSQMNLYKDVMLETYWNLTSIGYKWEDHHIEEPCQSSRRHTRHVRSHSWKKLYECN----- 78

  Fly   212 GVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKH--QTPVGSKE-EARELEKEQV-PQSAKRTSR 272
                                ...|..|...:.::  :|..|.|. |.....|... |...:|..|
Mouse    79 --------------------QCGKAFTSHSSLRYHKRTHTGEKPYECNHCGKAFARPAHLQRHKR 123

  Fly   273 RRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAG 337
                            .....|.:......|..:..:|......|.:|     |..|.|::|...
Mouse   124 ----------------THTGEKPYECNQCSKAFSCHSGLRYHKRTHTG-----EKPYECNQCGKA 167

  Fly   338 FAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEAL 398
            ||....|..|:| ..|  .:.|:||:|.|.|..|.:|..|:.:|..   :.|.:||.....:..|
Mouse   168 FARPADLQCHKRTHTG--EKPYECNQCGKAFARPANLQCHKRTHTGEKPYECNQCGKAFSCQGGL 230

  Fly   399 SKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHS 463
            ..|. :.|......:||.|.|.|...|.|:.|.|.||||||:.||.|||:|:.:.:||.||..|:
Mouse   231 RYHK-RTHTGEKPYECNQCGKAFARPSHLQCHKRTHTGEKPYECNQCGKAFSSHISLRYHKRTHT 294

  Fly   464 ETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDL 528
            ..|.::|..|..:|...:.|..|.|||||:||:||..|...|.|...|..|||.||||:||.|:.
Mouse   295 GEKPYECNQCGKAFSGHSGLRYHKRTHTGEKPYECNQCGKAFATPSHLQCHKRTHTGEKPYECNQ 359

  Fly   529 CPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMP 593
            |...|.....|::|:||||||:||.|..|.|.|.:....|.|:|||.||:.|.|..|.:.|....
Mouse   360 CSKAFARPAHLQHHKRTHTGEKPYECNQCGKAFARLSHLQCHKRTHTGEKPYECNQCGKAFSCHN 424

  Fly   594 EMRSHLAGH--------EQHDKRLVHFTFLS-NKENGSG 623
            .:|.|...|        .|..|.|...|.|. :|...:|
Mouse   425 SLRYHKGTHTGEKPYECNQCGKALATSTHLQCHKRTHTG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	88/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Zfp998	NP_001277125.1	KRAB	4..>46	CDD:214630	8/26 (31%)
		KRAB	4..43	CDD:279668	8/23 (35%)
		COG5048	72..452	CDD:227381	132/428 (31%)
		C2H2 Zn finger	77..97	CDD:275368	4/44 (9%)
		zf-H2C2_2	89..114	CDD:290200	5/24 (21%)
		C2H2 Zn finger	105..125	CDD:275368	4/35 (11%)
		zf-H2C2_2	117..142	CDD:290200	4/40 (10%)
		C2H2 Zn finger	133..153	CDD:275368	2/19 (11%)
		zf-H2C2_2	146..170	CDD:290200	7/28 (25%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..198	CDD:290200	10/26 (38%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		zf-H2C2_2	201..226	CDD:290200	6/24 (25%)
		C2H2 Zn finger	217..237	CDD:275368	5/20 (25%)
		zf-H2C2_2	230..254	CDD:290200	8/24 (33%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		zf-H2C2_2	257..282	CDD:290200	15/24 (63%)
		C2H2 Zn finger	273..293	CDD:275368	10/19 (53%)
		zf-H2C2_2	285..309	CDD:290200	8/23 (35%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	314..338	CDD:290200	13/23 (57%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	341..366	CDD:290200	13/24 (54%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	369..394	CDD:290200	14/24 (58%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	11/24 (46%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000