DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF99

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	307	Identity:	108/307 - (35%)
Similarity:	148/307 - (48%)	Gaps:	21/307 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSL----MIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA-- 382
            |.|..|.|:.|...|.....|    :||..:|.|     ||.||.|.|.....|.:|:..|..
Human   476 TGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPC-----KCEECGKAFKHFSALRKHKIIHTGKK 535

  Fly   383 -HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICG 446
             :.|.|||...::...|.||.:. |......:|..|.|.|...|.|..|..|||||||:.|..||
Human   536 PYKCEECGKAFNNSSTLMKHKII-HTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECG 599

  Fly   447 KSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSL 511
            |:|...:.||:|::.|:..|.:|||.|..:|...:.|..|...|||:||::||.|...|..|..|
Human   600 KAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHL 664

  Fly   512 AKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQG 576
            .:||..||.|:||.|:.|...|...:.|:.|:..|||::||.|..|.|.|:|....:.|:..|.|
Human   665 TRHKVIHTEEKPYKCEECGKAFNHFSALRKHKIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTG 729

  Fly   577 ERIYICPVCNEEFKSMPEMRSHLAGH--------EQHDKRLVHFTFL 615
            |:.|.|..|.:.||...::..|...|        |:..|...||:.|
Human   730 EKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKHFSAL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	81/215 (38%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	79/213 (37%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..352	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..491	CDD:290200	5/14 (36%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		zf-H2C2_2	523..548	CDD:290200	7/24 (29%)
		COG5048	534..857	CDD:227381	88/244 (36%)
		C2H2 Zn finger	539..559	CDD:275368	7/20 (35%)
		zf-H2C2_2	552..576	CDD:290200	8/24 (33%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		zf-H2C2_2	579..604	CDD:290200	14/24 (58%)
		C2H2 Zn finger	595..615	CDD:275368	8/19 (42%)
		zf-H2C2_2	607..632	CDD:290200	10/24 (42%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		zf-H2C2_2	636..659	CDD:290200	10/22 (45%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		zf-H2C2_2	663..688	CDD:290200	11/24 (46%)
		C2H2 Zn finger	679..699	CDD:275368	5/19 (26%)
		zf-H2C2_2	691..716	CDD:290200	11/24 (46%)
		C2H2 Zn finger	707..727	CDD:275368	6/19 (32%)
		zf-H2C2_2	720..743	CDD:290200	7/22 (32%)
		C2H2 Zn finger	735..755	CDD:275368	5/19 (26%)
		C2H2 Zn finger	763..783	CDD:275368	5/14 (36%)
		zf-H2C2_2	775..800	CDD:290200	1/2 (50%)
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910