DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF84

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	451	Identity:	136/451 - (30%)
Similarity:	195/451 - (43%)	Gaps:	81/451 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 HQTPVGSK----EEARELEKEQVPQSAKRTSRRRGVVK------QDVPATPPSDAEPSPKQ---- 295
            |:..:|.|    .|.|           ||.|::..::|      :|:.....:..:..|::
Human   198 HRNRLGEKLYECSECR-----------KRFSKKPSLIKHQSRHIRDIAFGCGNCGKTFPQKSQFI 251

  Fly   296 --HRLGTQRK----LSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIH-RRQKGC 353
              ||..|..|    ....:|.:.....|:.....|.|..|.|..|...|:.:..|:.| |...|
Human   252 THHRTHTGEKPYNCSQCGKAFSQKSQLTSHQRTHTGEKPYECGECGKAFSRKSHLISHWRTHTG- 315

  Fly   354 INRNYKCNECEKVFVSPDHLAEHQASHGAH---NCPECGIRCDSKEALSKHMVQGHKRN------ 409
             .:.|.||||.:.|....:|..||..|...   .|.|||.....|..|..|    |:.:
Human   316 -EKPYGCNECGRAFSEKSNLINHQRIHTGEKPFECRECGKAFSRKSQLVTH----HRTHTGTKPF 375

  Fly   410 ---------------LRNQ----------CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSF 449
                           :|:|          |:.|:|.|...|:|.:|.|.||||||..|..|||:|
Human   376 GCSDCRKAFFEKSELIRHQTIHTGEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAF 440

  Fly   450 TQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKH 514
            :|.::|..|::.|:..|.|.|..|..:|..|::|..|.|||||:||:||..|...|:...||..|
Human   441 SQKSHLISHQMTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTGEKPYECSECGKAFSEKLSLTNH 505

  Fly   515 KRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERI 579
            :|.||||:||.|..|...|...:.|.:|:||||||:||.|..|.|.|.::.....|||||.||:.
Human   506 QRIHTGEKPYVCSECGKAFCQKSHLISHQRTHTGEKPYECSECGKAFGEKSSLATHQRTHTGEKP 570

  Fly   580 YICPVCNEEFKSMPEMRSHL---AGHEQHDKRLVHFTFLSNKE------NGSGALEEELNE 631
            |.|..|.:.|....::.:|.   .|.:.::..|....|....|      ..:|....|.||
Human   571 YECRDCEKAFSQKSQLNTHQRIHTGEKPYECSLCRKAFFEKSELIRHLRTHTGEKPYECNE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	89/246 (36%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/22 (18%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368	6/30 (20%)
		C2H2 Zn finger	237..257	CDD:275368	3/19 (16%)
		C2H2 Zn finger	265..285	CDD:275368	2/19 (11%)
		zf-H2C2_2	278..302	CDD:316026	7/23 (30%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		COG5048	317..724	CDD:227381	109/319 (34%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..369	CDD:275368	8/23 (35%)
		C2H2 Zn finger	377..397	CDD:275368	2/19 (11%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368	3/19 (16%)
		C2H2 Zn finger	629..649	CDD:275368	2/3 (67%)
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910