DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF43

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens

Alignment Length:	419	Identity:	133/419 - (31%)
Similarity:	188/419 - (44%)	Gaps:	52/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 ECNLAIFEGVDNEAEIITV-----TAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQV 263
            ||..|.     |::.|:|.     |..:....|..||...|..|         ..|.:::...:.
Human   271 ECGKAF-----NKSSILTTHKIIRTGEKFYKCKECAKAFNQSSN---------LTEHKKIHPGEK 321

  Fly   264 PQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPS-------TTSGA 321
            |...:...:     ..:.|:|       ..|..|:.|..|   |......|.:       ||...
Human   322 PYKCEECGK-----AFNWPST-------LTKHKRIHTGEK---PYTCEECGKAFNQFSNLTTHKR 371

  Fly   322 ATTPELKYHCDRCNAGFAVEKSLMIHRR---QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA- 382
            ..|.|..|.|..|...|:...:|..|::   :|    :.|||.||.|.|.....|.||:.:|..
Human   372 IHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEK----KPYKCEECGKAFKWSSKLTEHKLTHTGE 432

  Fly   383 --HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNIC 445
              :.|.|||...:....|:||. :.|......:|.:|.|.|...|.|..|.||||.|||:.|..|
Human   433 KPYKCEECGKAFNWPSTLTKHN-RIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKCEEC 496

  Fly   446 GKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS 510
            ||:|::::||.:||..|.|.|.:|||.|..:|...::||.|..||||:||::||.|...|.....
Human   497 GKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSI 561

  Fly   511 LAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQ 575
            |.||||.||||:||.|:.|...||..:.|..|::.||||:.|.|..|.|.|||..:...|::.|.
Human   562 LTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIHT 626

  Fly   576 GERIYICPVCNEEFKSMPEMRSHLAGHEQ 604
            |.:.|.|..|.:.|.....:..|...|.:
Human   627 GGKPYKCEECGKAFNQFSTLTKHKIIHTE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/25 (24%)
		COG5048	<357..570	CDD:227381	91/215 (42%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368	6/22 (27%)
		COG5048	295..763	CDD:227381	126/390 (32%)
		C2H2 Zn finger	297..317	CDD:275368	6/28 (21%)
		zf-H2C2_2	309..333	CDD:290200	3/37 (8%)
		C2H2 Zn finger	325..345	CDD:275368	4/31 (13%)
		zf-H2C2_2	338..362	CDD:290200	6/26 (23%)
		C2H2 Zn finger	353..373	CDD:275368	3/19 (16%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	393..417	CDD:290200	9/27 (33%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	422..445	CDD:290200	8/22 (36%)
		C2H2 Zn finger	437..457	CDD:275368	7/20 (35%)
		zf-H2C2_2	450..474	CDD:290200	8/24 (33%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		zf-H2C2_2	477..502	CDD:290200	14/24 (58%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..558	CDD:290200	13/23 (57%)
		C2H2 Zn finger	549..569	CDD:275368	9/19 (47%)
		zf-H2C2_2	562..586	CDD:290200	14/23 (61%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		zf-H2C2_2	589..614	CDD:290200	11/24 (46%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		zf-H2C2_2	617..642	CDD:290200	7/24 (29%)
		C2H2 Zn finger	633..653	CDD:275368	4/19 (21%)
		C2H2 Zn finger	661..681	CDD:275368
		zf-H2C2_2	674..697	CDD:290200
		C2H2 Zn finger	689..709	CDD:275368
		zf-H2C2_2	702..726	CDD:290200
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910