DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF33B

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001291962.1	Gene:	ZNF33B / 7582	HGNCID:	13097	Length:	785	Species:	Homo sapiens

Alignment Length:	329	Identity:	120/329 - (36%)
Similarity:	164/329 - (49%)	Gaps:	16/329 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 STTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCI-NRNYKCNECEKVFVSPDHLAEHQAS 379
            ||.|.....|...|.|......|  .:.|.:.:.|||.. .::::||||.|.|....||..||..
Human   295 STLSKHDGVPVKHYDCGESGNNF--RRKLCLSQLQKGDKGEKHFECNECGKAFWEKSHLTRHQRV 357

  Fly   380 HGAH---NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFV 441
            |...   .|.:||.....|..|:||. :.|......:||.|.|.|:..|.|..|.|.||||||:.
Human   358 HTGEKHFQCNQCGKTFWEKSNLTKHQ-RSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQ 421

  Fly   442 CNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFT 506
            ||.|||:|.|.::|.:|:..|:..|.::|..|..||...:.||.|.|||||:|||||..|...|.
Human   422 CNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTGEKPFECLECGKSFC 486

  Fly   507 TSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQ 571
            ....|.:|:|.|.|::||.|:.|...|...:||..|:..|||.:||.|..|.|||..:.|..:||
Human   487 QKSHLTQHQRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYECGKTFCLKSDLTIHQ 551

  Fly   572 RTHQGERIYICPVCNEEFKSMPEMRSHLAGH------EQHD--KRLVHFTFLS-NKENGSGALEE 627
            |||.||:.:.||.|.:.|.....:..|...|      |.|:  |...:.::|: :....:|....
Human   552 RTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPY 616

  Fly   628 ELNE 631
            |.||
Human   617 ECNE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/22 (27%)
		COG5048	<357..570	CDD:227381	88/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	15/24 (63%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF33B	NP_001291962.1	KRAB	19..78	CDD:214630
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	310..330	CDD:275368	5/21 (24%)
		COG5048	336..681	CDD:227381	109/286 (38%)
		C2H2 Zn finger	338..358	CDD:275368	10/19 (53%)
		zf-H2C2_2	350..374	CDD:290200	8/23 (35%)
		C2H2 Zn finger	366..386	CDD:275368	7/20 (35%)
		zf-H2C2_2	378..403	CDD:290200	9/25 (36%)
		C2H2 Zn finger	394..414	CDD:275368	9/19 (47%)
		zf-H2C2_2	406..429	CDD:290200	14/22 (64%)
		C2H2 Zn finger	422..442	CDD:275368	9/19 (47%)
		zf-H2C2_2	434..457	CDD:290200	6/22 (27%)
		C2H2 Zn finger	450..470	CDD:275368	8/19 (42%)
		zf-H2C2_2	462..485	CDD:290200	14/22 (64%)
		zf-C2H2	476..498	CDD:278523	8/21 (38%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
		zf-H2C2_2	546..571	CDD:290200	12/24 (50%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		zf-H2C2_2	575..597	CDD:290200	5/21 (24%)
		C2H2 Zn finger	590..610	CDD:275368	3/19 (16%)
		zf-H2C2_2	602..625	CDD:290200	5/19 (26%)
		C2H2 Zn finger	618..638	CDD:275368	2/3 (67%)
		zf-H2C2_2	631..653	CDD:290200
		C2H2 Zn finger	646..666	CDD:275368
		zf-H2C2_2	658..681	CDD:290200
		COG5048	668..>727	CDD:227381
		C2H2 Zn finger	674..694	CDD:275368
		zf-H2C2_2	690..711	CDD:290200
		C2H2 Zn finger	702..722	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368
		zf-H2C2_2	742..767	CDD:290200
		C2H2 Zn finger	758..778	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000