DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF33A

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001265106.1	Gene:	ZNF33A / 7581	HGNCID:	13096	Length:	832	Species:	Homo sapiens

Alignment Length:	339	Identity:	118/339 - (34%)
Similarity:	152/339 - (44%)	Gaps:	63/339 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGAH---NCP 386
            |..:.|:.|...|..:..|..|:| ..|  .:.::||||||.|....:|.:||.||...   .|.
Human   347 EKHFECNECGKAFWEKSHLTRHQRVHTG--QKPFQCNECEKAFWDKSNLTKHQRSHTGEKPFECN 409

  Fly   387 ECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKV----------------------------FTM 423
            |||.....|.||:.|. :.|......|||.|.|.                            |.:
Human   410 ECGKAFSHKSALTLHQ-RTHTGEKPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSFRV 473

  Fly   424 LSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELC--------------- 473
            .|.|:.|.|.|||||||.|..|||||::.:||.||:..|...||::|..|
Human   474 TSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKSLLTRHQI 538

  Fly   474 ------PH-------SFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYA 525
                  |:       :|..|::||.|.|||||.|||.|..|...|:...:|::|.|.||||:||.
Human   539 IHTGWKPYECYECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEKPYE 603

  Fly   526 CDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFK 590
            |..|...|...:.|..|.||||||:||.|..|.|.|.|:.....|||.|.||:.|.|..|.:.|.
Human   604 CHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGKAFC 668

  Fly   591 SMPEMRSHLAGHEQ 604
            ....:..|...|.|
Human   669 HKSALIVHQRTHTQ 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	97/271 (36%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	9/47 (19%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	22/75 (29%)
		C2H2 Zn finger	470..487	CDD:275368	7/44 (16%)
		zf-H2C2_2	482..507	CDD:290200	14/24 (58%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF33A	NP_001265106.1	KRAB	33..92	CDD:214630
		KRAB	33..72	CDD:279668
		COG5048	163..537	CDD:227381	61/192 (32%)
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:290200	10/25 (40%)
		C2H2 Zn finger	380..400	CDD:275368	10/19 (53%)
		zf-H2C2_2	392..417	CDD:290200	9/24 (38%)
		C2H2 Zn finger	408..428	CDD:275368	8/20 (40%)
		zf-H2C2_2	420..443	CDD:290200	9/23 (39%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		COG5048	444..820	CDD:227381	84/239 (35%)
		zf-H2C2_2	448..471	CDD:290200	0/22 (0%)
		C2H2 Zn finger	464..484	CDD:275368	5/19 (26%)
		zf-H2C2_2	476..500	CDD:290200	15/23 (65%)
		C2H2 Zn finger	492..512	CDD:275368	10/19 (53%)
		C2H2 Zn finger	520..540	CDD:275368	2/19 (11%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		zf-H2C2_2	560..585	CDD:290200	14/24 (58%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		zf-H2C2_2	589..611	CDD:290200	11/21 (52%)
		C2H2 Zn finger	604..624	CDD:275368	6/19 (32%)
		zf-H2C2_2	616..639	CDD:290200	13/22 (59%)
		C2H2 Zn finger	632..652	CDD:275368	8/19 (42%)
		zf-H2C2_2	645..667	CDD:290200	9/21 (43%)
		C2H2 Zn finger	660..680	CDD:275368	4/19 (21%)
		zf-H2C2_2	672..695	CDD:290200	3/11 (27%)
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		zf-H2C2_2	756..781	CDD:290200
		C2H2 Zn finger	772..792	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000