DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF23

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001368913.1	Gene:	ZNF23 / 7571	HGNCID:	13023	Length:	686	Species:	Homo sapiens

Alignment Length:	598	Identity:	167/598 - (27%)
Similarity:	246/598 - (41%)	Gaps:	121/598 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EPDSKVSISCPVA--TTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDL--DYE 147
            |..|::..|.|:|  |..|.:|         |..:|||...|.:..:.    |..:|.:|  |:.
Human    67 EGGSELGGSSPLAAGTGLQGLQ---------TVDIQTDNDLTKEMYEG----KENVSFELQRDFS 118

  Fly   148 GEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEG 212
            .|.:..:..|.::..|      :...||:|.||      :|.| :|...:....:.||   .|..
Human   119 QETDFSEASLLEKQQE------VHSAGNIKKEK------SNTI-DGTVKDETSPVEEC---FFSQ 167

  Fly   213 VDNEAEIITVTAPQ-----------------------------------VTTRKSAAKLLTQQEN 242
            ..|..:..|:|..|                                   |...:..::|:..|||
Human   168 SSNSYQCHTITGEQPSGCTGLGKSISFDTKLVKHEIINSEERPFKCEELVEPFRCDSQLIQHQEN 232

  Fly   243 DKHQTPVGSKEEAR------------ELEKEQVP----QSAKRTSRRRGVVKQDVPATPPSDAEP 291
            :..:.|....|..:            .|...:.|    :..|..|.....:...   |..|..:|
Human   233 NTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQ---TIHSGEKP 294

  Fly   292 --------------SPKQH-RLGT-QRKLSAPRAGTVNGPSTTSGAAT-----TPELKYHCDRCN 335
                          |..:| |:.| ::.......|  ||.|.:|...|     |.|..|.|:.|.
Human   295 YQCKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECG--NGFSCSSAYITHQRVHTGEKPYECNDCG 357

  Fly   336 AGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKE 396
            ..|.|...|:.|:| ..|  .:.|:||||.|.|.....|.:||:.|..   :.|.|||...::..
Human   358 KAFNVNAKLIQHQRIHTG--EKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNNNT 420

  Fly   397 ALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLR 461
            .|.:|. :.|......:|..|.|.|::...|..|.||||||||:.||.|||:|..|:..|||...
Human   421 KLIQHQ-RIHTGEKPYECTECGKAFSVKGKLIQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRI 484

  Fly   462 HSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYAC 526
            |:..|.::|..|..:|....:|..|.|.|||:|||||..|...||:..:|..|.|.||||:||.|
Human   485 HTGEKPYECNECGKAFSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQC 549

  Fly   527 DLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKS 591
            ..|...|:....|..|:|.||||:|:.|..|.|.|:...:..:|||.|.||:.:.|..|.:.|
Human   550 KECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSNYIVHQRIHTGEKPFQCKECGKAF-- 612

  Fly   592 MPEMRSHLAGHEQ 604
              .:.:||..|::
Human   613 --HVNAHLIRHQR 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	85/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF23	NP_001368913.1	KRAB	14..73	CDD:214630	2/5 (40%)
		C2H2 Zn finger	185..205	CDD:275368	0/19 (0%)
		C2H2 Zn finger	213..233	CDD:275368	4/19 (21%)
		COG5048	229..649	CDD:227381	130/407 (32%)
		C2H2 Zn finger	241..261	CDD:275368	1/19 (5%)
		C2H2 Zn finger	269..289	CDD:275368	3/22 (14%)
		C2H2 Zn finger	297..317	CDD:275368	3/19 (16%)
		C2H2 Zn finger	325..345	CDD:275368	6/21 (29%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	9/19 (47%)
		C2H2 Zn finger	409..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	465..485	CDD:275368	10/19 (53%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		C2H2 Zn finger	605..625	CDD:275368	6/23 (26%)
		C2H2 Zn finger	633..653	CDD:275368
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910