DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF17

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001317546.1	Gene:	ZNF17 / 7565	HGNCID:	12958	Length:	664	Species:	Homo sapiens

Alignment Length:	560	Identity:	161/560 - (28%)
Similarity:	232/560 - (41%)	Gaps:	93/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYE 147
            |..||..||..:|..|:      |.|:.:|...|...|       ..|..:||:|..:.: .:::
Human    55 AKDEEAPSKQCVSVGVS------QVTTLKPALSTQKAQ-------PCETCSSLLKDILHL-AEHD 105

  Fly   148 GEGEVFDYELPDEPVEKTTSLILQVQGNLK------DEKEVVFTQTNV--------IYEG----- 193
            |          ..| ::|..|.|..:.:|:      ||....|...:|        ..:|
Human   106 G----------THP-KRTAKLYLHQKEHLREKLTRSDEGRPSFVNDSVHLAKRNLTCMQGGKDFT 159

  Fly   194 DDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEND-KHQTPVGSKEEARE 257
            .|.:|:||      |:..|.....:...|.|.|......:.   ||...| .||..:   .|.::
Human   160 GDSDLQQQ------ALHSGWKPHRDTHGVEAFQSGQNNYSC---TQCGKDFCHQHTL---FEHQK 212

  Fly   258 LEKEQVPQSAKRTSR----RRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTT 318
            :..|:.|.......:    ...::|.....|       ..:.::.....|..:.:...|......
Human   213 IHTEERPYECSECGKLFRYNSDLIKHQRNHT-------GERPYKCSECGKAFSLKYNVVQHQKIH 270

  Fly   319 SGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCIN---RNYKCNECEKVFVSPDHLAEHQASH 380
            :|     |..|.|..|...|..:..|:.|:|    |:   |.|.|:||.|.|::..||..||..|
Human   271 TG-----ERPYECSECGKAFLRKSHLLQHQR----IHTRPRPYVCSECGKAFLTQAHLVGHQKIH 326

  Fly   381 GA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVC 442
            ..   :.|.|||.......||.:|. :.|.......|..|.|.|....||..|.|:||||||:.|
Human   327 TGERPYGCNECGKYFMYSSALIRHQ-KVHTGERPFYCCECGKFFMDSCTLIIHQRVHTGEKPYEC 390

  Fly   443 NICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTT 507
            |.|||.|...:.|.:|:..|:..|.::|..|...|:..:.|..|.|.|||:||:||..|...|..
Human   391 NECGKFFRYRSTLIRHQKVHTGEKPYECSECGKFFMDTSTLIIHQRVHTGEKPYECNKCGKFFRY 455

  Fly   508 SCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQR 572
            ..:|.:|:|.|:|||||.|..|...|.....||:|:|.||||||:.|..|.|:|..|.....|||
Human   456 CFTLNRHQRVHSGERPYECSECGKFFVDSCTLKSHQRVHTGERPFECSICGKSFRCRSTLDTHQR 520

  Fly   573 THQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLVHF 612
            .|.|||.|.|..|.:.|:       |.:.|.:|  |..||
Human   521 IHTGERPYECSECGKFFR-------HNSNHIRH--RRNHF 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/22 (27%)
		COG5048	<357..570	CDD:227381	85/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF17	NP_001317546.1	KRAB	12..49	CDD:279668
		C2H2 Zn finger	151..180	CDD:275368	7/34 (21%)
		C2H2 Zn finger	194..214	CDD:275368	6/25 (24%)
		C2H2 Zn finger	222..242	CDD:275368	1/19 (5%)
		zf-H2C2_2	234..258	CDD:290200	3/30 (10%)
		COG5048	246..658	CDD:227381	115/325 (35%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		zf-H2C2_2	262..287	CDD:290200	7/29 (24%)
		C2H2 Zn finger	278..298	CDD:275368	6/23 (26%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	7/20 (35%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..482	CDD:290200	11/22 (50%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..511	CDD:290200	14/23 (61%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		zf-H2C2_2	515..539	CDD:290200	11/30 (37%)
		C2H2 Zn finger	530..550	CDD:275368	7/28 (25%)
		C2H2 Zn finger	558..578	CDD:275368
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	599..623	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	626..651	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000