DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF16

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001025147.2	Gene:	ZNF16 / 7564	HGNCID:	12947	Length:	682	Species:	Homo sapiens

Alignment Length:	282	Identity:	107/282 - (37%)
Similarity:	149/282 - (52%)	Gaps:	5/282 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNC 385
            |.|..:.||.|...|: :.|::.:|.:.....:.|:|:||.|.|......:.||:.|.:   :.|
Human   232 TGEASFMCDDCGKTFS-QNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQSHHSSERPYMC 295

  Fly   386 PECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFT 450
            .|||.......:|.||. :.|......:||.|.|.|...|.|..|.|||:||||:||:.|||:|.
Human   296 NECGKAFSQNSSLKKHQ-KSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFR 359

  Fly   451 QNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHK 515
            :::||.:|...|:..|.|:|..|..:|...|.|..|.|.|||:||:||..|...|:...:|.||.
Human   360 RSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFSRVSNLIKHH 424

  Fly   516 RKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIY 580
            |.||||:||.|..|...|:..:.|..|||.||||:|:||..|.|.|:.....:.||..|.||:.|
Human   425 RVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPY 489

  Fly   581 ICPVCNEEFKSMPEMRSHLAGH 602
            .|.||.:.|.....:..|...|
Human   490 RCSVCGKAFSHSSALIQHQGVH 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/22 (27%)
		COG5048	<357..570	CDD:227381	87/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF16	NP_001025147.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210
		COG5048	<160..369	CDD:227381	49/138 (36%)
		C2H2 Zn finger	187..203	CDD:275368
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368	6/20 (30%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		Required for nuclear localization	268..393		46/125 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/20 (35%)
		COG5048	303..675	CDD:227381	86/210 (41%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		Required for nuclear localization	341..373		17/31 (55%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		Required for nuclear localization	473..503		10/29 (34%)
		C2H2 Zn finger	491..511	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910