DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF10

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_056209.2	Gene:	ZNF10 / 7556	HGNCID:	12879	Length:	573	Species:	Homo sapiens

Alignment Length:	605	Identity:	163/605 - (26%)
Similarity:	241/605 - (39%)	Gaps:	108/605 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TLRQLL-PNALPEEPDSKVSISCPVATTDQAVQTTSWE--------------PDRCTASVQTDAV 124
            |.:|:: .|.:.|...:.||:...:...|..::....|              ||..||.....:|
Human    33 TAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSV 97

  Fly   125 TTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDE-KEVVFTQTN 188
            :      :.|:.|...|.|:..||......:.|..|.|.|....:.:.|.|.:.. ::|.|||..
Human    98 S------SRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKK 156

  Fly   189 VIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKE 253
            |:.:....|..:....|.|                ..|:..|:...|..:..::.||...:...:
Human   157 VLTQERVSESGKYGGNCLL----------------PAQLVLREYFHKRDSHTKSLKHDLVLNGHQ 205

  Fly   254 EARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTT 318
            ::......:..|:          ..|::.....:......|.::...            |..|.|
Human   206 DSCASNSNECGQT----------FCQNIHLIQFARTHTGDKSYKCPD------------NDNSLT 248

  Fly   319 SGAA------TTPELKYHCDRCNAGFAVEKSL----MIHRRQKGCINRNYKCNECEKVFVSPDHL 373
            .|::      ...|..|.|..|...|:...:|    :||..:|     .|:|.||.|.|....||
Human   249 HGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEK-----PYECKECGKSFSRSSHL 308

  Fly   374 AEHQASHGA---HNCPECGIRCDSKEALS--KHMVQGHKRNLRNQ----CNICQKVFTMLSTLRD 429
            ..||.:|..   :.|.|||      ::.|  .|:|. |:|.....    ||.|.|.|...|.|..
Human   309 IGHQKTHTGEEPYECKECG------KSFSWFSHLVT-HQRTHTGDKLYTCNQCGKSFVHSSRLIR 366

  Fly   430 HMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDK 494
            |.|.||||||:.|..|||||.|:.:|..|:..|...:.::|..|..|:..::.|..|.|.|||.|
Human   367 HQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHLVVHHRIHTGLK 431

  Fly   495 PFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSK 559
            ||||:.|...|:.|..|..|:|.||||:||.|..|...|:..:.|..|:|.||||:||.|..|.|
Human   432 PFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGK 496

  Fly   560 TFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH--EQHDKRLVHFTFLSNKE--- 619
            .|.::.|...|||.|.||..|.|..|...|........|...|  ||         ||:..:
Human   497 AFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQ---------FLTCNQCGT 552

  Fly   620 ---NGSGALEEELNEMTESA 636
               |.|..:..:.|.:.|:|
Human   553 ALVNTSNLIGYQTNHIRENA 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	1/3 (33%)
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	88/221 (40%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	7/22 (32%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF10	NP_056209.2	KRAB	14..73	CDD:214630	8/39 (21%)
		C2H2 Zn finger	213..232	CDD:275368	2/28 (7%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		COG5048	<272..474	CDD:227381	79/213 (37%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	9/26 (35%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	4/19 (21%)
		C2H2 Zn finger	547..567	CDD:275368	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910