DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF814

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001138461.1	Gene:	ZNF814 / 730051	HGNCID:	33258	Length:	855	Species:	Homo sapiens

Alignment Length:	308	Identity:	109/308 - (35%)
Similarity:	151/308 - (49%)	Gaps:	25/308 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRR---QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA--- 382
            |.:..|.|..|...|:...|...|:|   :|    ::|:|.||.|.|......:.||..|..
Human   319 TGKRPYECGECGKSFSKYASFSNHQRVHTEK----KHYECGECGKSFSKYVSFSNHQRVHTGKRP 379

  Fly   383 HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGK 447
            :.|.|||.......:.|.|. :.|......:|..|.|.|:..|:|..|.|.||||||:.|..|||
Human   380 YECGECGKSFSKYASFSNHQ-RVHTDKKHYECGECGKSFSQKSSLIQHQRFHTGEKPYGCEECGK 443

  Fly   448 SFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLA 512
            ||:...:||.|:..|:..:.|||..|..||..|..|..|.|.|:|::|::|..|...|:...:|.
Human   444 SFSSEGHLRSHQRVHAGERPFKCGECVKSFSHKRSLVHHQRVHSGERPYQCGECGKSFSQKGNLV 508

  Fly   513 KHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGE 577
            .|:|.|||.|||.|..|...|::...|:||::.|||:|.|.|..|.|:|:.:|...:|||.|..|
Human   509 LHQRVHTGARPYECGECGKSFSSKGHLRNHQQIHTGDRLYECGECGKSFSHKGTLILHQRVHPRE 573

  Fly   578 RIYICPVCNEEFKSMPEMRSHLAGHE--------------QHDKRLVH 611
            |.|.|..|.:.|.|:..:|||...|.              .|.:.|||
Human   574 RSYGCGECGKSFSSIGHLRSHQRVHTGERPYECGECGKSFSHKRSLVH 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/25 (28%)
		COG5048	<357..570	CDD:227381	81/215 (38%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF814	NP_001138461.1	KRAB	15..>56	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	176..192	CDD:275368
		COG5048	214..650	CDD:227381	109/308 (35%)
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	271..291	CDD:275368
		C2H2 Zn finger	298..318	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	6/20 (30%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)
		COG5048	462..850	CDD:227381	60/160 (38%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		C2H2 Zn finger	522..542	CDD:275368	6/19 (32%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		C2H2 Zn finger	578..598	CDD:275368	7/19 (37%)
		zf-H2C2_2	590..615	CDD:290200	4/24 (17%)
		C2H2 Zn finger	606..626	CDD:275368	4/16 (25%)
		C2H2 Zn finger	634..654	CDD:275368
		zf-H2C2_2	646..671	CDD:290200
		C2H2 Zn finger	662..682	CDD:275368
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
		zf-H2C2_2	786..810	CDD:290200
		C2H2 Zn finger	802..822	CDD:275368
		zf-H2C2_2	814..838	CDD:290200
		C2H2 Zn finger	830..850	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910