DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and GZF1

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001303941.1	Gene:	GZF1 / 64412	HGNCID:	15808	Length:	711	Species:	Homo sapiens

Alignment Length:	622	Identity:	185/622 - (29%)
Similarity:	250/622 - (40%)	Gaps:	123/622 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAE 130
            |:||.:.|.|..||....|     ..|.:.....:..|.|:.:|  ..:.:|:....|...||..
Human   115 KLKCLDLSETCFQLKKQML-----ESVLLELQNFSESQEVEVSS--GSQVSAAPAPRASVATDGP 172

  Fly   131 QNTSLIKSTISVDLDYEGE--GEVFDYELP-----------DEPVEKTTSLILQVQGNLKDEKEV 182
            ..:.|..|     |||.||  ......:||           .|.|:.....|.:..|.|...|..
Human   173 HPSGLTDS-----LDYPGERASNGMSSDLPPKKSKDKLDKKKEVVKPPYPKIRRASGRLAGRKVF 232

  Fly   183 V----------FTQTNVIYEGD--DHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAK 235
            |          ..:.....|||  |:...|             |...:.:.....||:..:....
Human   233 VEIPKKKYTRRLREQQKTAEGDVGDYRCPQ-------------DQSPDRVGTEMEQVSKNEGCQA 284

  Fly   236 LLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGT 300
            ....:|..|...|     |..|.|:|:..:..|:.|..:..:.:.......|..:.|..:|
Human   285 GAELEELSKKAGP-----EEEEEEEEEDEEGEKKKSNFKCSICEKAFLYEKSFLKHSKHRH---- 340

  Fly   301 QRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEK 365
                               |.||  |:.|.||.|...||...:|..|:|......|::.|..|.|
Human   341 -------------------GVAT--EVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCELCGK 384

  Fly   366 VF-----VSPDHLAEHQASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLS 425
            .|     |....|..|:.....|.|.:||....||.||..| .:.|..:....|..|...|:..|
Human   385 KFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLH-ERTHTGDRPYGCTECGARFSQPS 448

  Fly   426 TLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTH 490
            .|:.|||||||||||||:.||..||||..|..||..|:..:.|.||.|..||.:|..|..|.|.|
Human   449 ALKTHMRIHTGEKPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNRIH 513

  Fly   491 TGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCP 555
            ||.|||:||||...|....||.:|.:.|||||||.||.|..:||.||.|:.|||.||||||::|.
Human   514 TGSKPFKCEVCFRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQLNALQRHRRIHTGERPFMCN 578

  Fly   556 FCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLA----------GH--EQHDKR 608
            .|.:|||.:...:.|...|.              |:.| .:|.|.          ||  ||.|:.
Human   579 ACGRTFTDKSTLRRHTSIHD--------------KNTP-WKSFLVIVDGSPKNDDGHKTEQPDEE 628

  Fly   609 LVHFTFLSNK-----ENGS----GALEEELNEMTESA 636
            .|. :.||:|     |||.    .|:::.:..|.|::
Human   629 YVS-SKLSDKLLSFAENGHFHNLAAVQDTVPTMQENS 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	5/12 (42%)
		C2H2 Zn finger	331..354	CDD:275368	8/22 (36%)
		COG5048	<357..570	CDD:227381	98/217 (45%)
		C2H2 Zn finger	360..380	CDD:275368	7/24 (29%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	17/23 (74%)
		C2H2 Zn finger	442..490	CDD:275368	21/47 (45%)
		C2H2 Zn finger	470..487	CDD:275368	7/16 (44%)
		zf-H2C2_2	482..507	CDD:290200	14/24 (58%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	11/19 (58%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/29 (14%)
GZF1	NP_001303941.1	BTB	21..133	CDD:306997	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..220		16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..312		15/86 (17%)
		C2H2 Zn finger	319..339	CDD:275368	2/19 (11%)
		C2H2 Zn finger	350..371	CDD:275368	8/20 (40%)
		COG5048	<405..593	CDD:227381	91/188 (48%)
		C2H2 Zn finger	409..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	10/19 (53%)
		C2H2 Zn finger	493..513	CDD:275368	9/19 (47%)
		C2H2 Zn finger	521..541	CDD:275368	8/19 (42%)
		C2H2 Zn finger	549..569	CDD:275368	11/19 (58%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910