DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6654 and Hic2

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_849253.2 Gene:Hic2 / 58180 MGIID:1929869 Length:619 Species:Mus musculus


Alignment Length:567 Identity:121/567 - (21%)
Similarity:189/567 - (33%) Gaps:208/567 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 CLSSTGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSR 74
            |.:||       :|.||.|..::..:.:|..|......|.                         
Mouse   229 CSTST-------NGSSGGCEQELGLDLSKKSPPLPPTTPG------------------------- 261

  Fly    75 TLRQLLPNALPEEP----DSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSL 135
                  |:..||:|    ||:.....|.:|:...|..::       :.|:..|.           
Mouse   262 ------PHLTPEDPAQLSDSQRESPAPTSTSALPVGNSA-------SFVELGAT----------- 302

  Fly   136 IKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQ 200
                                  |:||::        |:|                          
Mouse   303 ----------------------PEEPMD--------VEG-------------------------- 311

  Fly   201 QIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEAREL-EKEQVP 264
             ..|.:|::.||...:        |:.:.|.||.|    ::.:|.:...||..:.||. .|...|
Mouse   312 -AEENHLSLLEGQGGQ--------PRKSLRHSARK----KDWNKKEPVAGSPFDRRETGSKGSCP 363

  Fly   265 -QSAKRTSRR--RGVVKQDVPATPPS-----DAEPSPKQHRLGTQRKLSAPRAGTVNGPSTT--- 318
             :..:.|..|  .||:........||     .:.|..::...|......:.::|:..|...|   
Mouse   364 GEEGEGTGDRVPNGVLASSAGGGGPSASYGEQSFPCKEEEENGKDGSEDSGQSGSEGGSGHTGAH 428

  Fly   319 -----SGAATTP--ELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEH 376
                 .|..|..  :..|.|..|..||...:.|          |.:.:.:..|::|:..:. |..
Mouse   429 YVYRQEGYETVSYGDNVYVCIPCAKGFPSSEQL----------NAHVETHTEEELFIKEEG-AYE 482

  Fly   377 QASHGAH------NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHT 435
            ..|.||.      :.|......||:..               :|::|:|.:...:|||.|.:.|.
Mouse   483 TGSGGAEEEAEDLSTPSAAYTADSRPF---------------KCSVCEKTYKDPATLRQHEKTHW 532

  Fly   436 GEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEV 500
            ..:||.||||||.|||                            :..:|.|.|:|.|.|||.|:.
Mouse   533 LTRPFPCNICGKMFTQ----------------------------RGTMTRHMRSHLGLKPFACDE 569

  Fly   501 CLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547
            |..|||....|.:|.|.|:||:||.|.||..:||....|.:|.|.||
Mouse   570 CGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHT 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 10/68 (15%)
C2H2 Zn finger 331..354 CDD:275368 5/22 (23%)
COG5048 <357..570 CDD:227381 59/197 (30%)
C2H2 Zn finger 360..380 CDD:275368 3/19 (16%)
C2H2 Zn finger 385..406 CDD:275370 3/20 (15%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 427..451 CDD:290200 13/23 (57%)
C2H2 Zn finger 442..490 CDD:275368 12/47 (26%)
C2H2 Zn finger 470..487 CDD:275368 1/16 (6%)
zf-H2C2_2 482..507 CDD:290200 12/24 (50%)
C2H2 Zn finger 498..518 CDD:275368 8/19 (42%)
zf-H2C2_2 510..534 CDD:290200 11/23 (48%)
C2H2 Zn finger 526..546 CDD:275368 8/19 (42%)
zf-H2C2_2 539..563 CDD:290200 5/9 (56%)
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
Hic2NP_849253.2 BTB 40..140 CDD:279045
BTB 47..141 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..293 19/101 (19%)
Binding to CtBP. /evidence=ECO:0000250 247..249 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..426 28/165 (17%)
C2H2 Zn finger 448..468 CDD:275368 6/29 (21%)
zf-C2H2 509..531 CDD:278523 7/36 (19%)
C2H2 Zn finger 511..531 CDD:275368 7/19 (37%)
zf-C2H2 537..559 CDD:278523 13/49 (27%)
C2H2 Zn finger 539..559 CDD:275368 12/47 (26%)
zf-H2C2_2 552..576 CDD:290200 12/23 (52%)
COG5048 563..>617 CDD:227381 26/54 (48%)
C2H2 Zn finger 567..587 CDD:275368 8/19 (42%)
zf-H2C2_2 580..604 CDD:290200 12/23 (52%)
C2H2 Zn finger 595..615 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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