DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF492

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_065906.1	Gene:	ZNF492 / 57615	HGNCID:	23707	Length:	531	Species:	Homo sapiens

Alignment Length:	286	Identity:	111/286 - (38%)
Similarity:	150/286 - (52%)	Gaps:	11/286 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 TTPELKYHCDRCNAGFAVEKSLMIHR-RQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---H 383
            ||....:.||:....|....:...|. |..|  .:::||.||||.|....|||:|:..|..   :
Human   107 TTQNKIFQCDKYVKVFHKFSNSNRHTIRHTG--KKSFKCKECEKSFCMLSHLAQHKRIHSGEKPY 169

  Fly   384 NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKS 448
            .|.|||...:....||.|. :.|......:|..|.|.|..||.|..|..||||:||:.|..|||:
Human   170 KCKECGKAYNETSNLSTHK-RIHTGKKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYKCEECGKA 233

  Fly   449 FTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAK 513
            |.|:|||..||..|:..|.:|||.|..:|...:.||:|...|.|:||::||.|...|:.|.:|..
Human   234 FNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKIIHAGEKPYKCEECGKAFSQSSTLTT 298

  Fly   514 HKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGER 578
            ||..||||:.|.|:.|...|:.|:.|..|:|.|:||:||.|..|.|.|.|......|:|.|.||:
Human   299 HKIIHTGEKFYKCEECGKAFSQLSHLTTHKRIHSGEKPYKCEECGKAFKQSSTLTTHKRIHAGEK 363

  Fly   579 IYICPVCNEEFKSMPEMRSHLAGHEQ 604
            .|.|.||::.|...    |||..|::
Human   364 FYKCEVCSKAFSRF----SHLTTHKR 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/23 (26%)
		COG5048	<357..570	CDD:227381	89/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	21/47 (45%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF492	NP_065906.1	KRAB	<1..32	CDD:214630
		COG5048	138..522	CDD:227381	103/253 (41%)
		C2H2 Zn finger	143..163	CDD:275368	10/19 (53%)
		zf-H2C2_2	155..179	CDD:290200	9/23 (39%)
		C2H2 Zn finger	171..191	CDD:275368	7/20 (35%)
		zf-H2C2_2	183..208	CDD:290200	8/25 (32%)
		C2H2 Zn finger	199..219	CDD:275368	8/19 (42%)
		zf-H2C2_2	211..236	CDD:290200	13/24 (54%)
		C2H2 Zn finger	227..247	CDD:275368	11/19 (58%)
		zf-H2C2_2	239..264	CDD:290200	11/24 (46%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..348	CDD:290200	12/24 (50%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	8/23 (35%)
		zf-H2C2_2	379..403	CDD:290200	3/7 (43%)
		C2H2 Zn finger	395..415	CDD:275368
		zf-H2C2_2	408..432	CDD:290200
		C2H2 Zn finger	423..443	CDD:275368
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..488	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910