DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF490

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_065765.1	Gene:	ZNF490 / 57474	HGNCID:	23705	Length:	529	Species:	Homo sapiens

Alignment Length:	412	Identity:	119/412 - (28%)
Similarity:	182/412 - (44%)	Gaps:	55/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 TAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQV----PQSAKRTSRRRGVVKQDVPA 283
            ::.|..|....:.:|..|.::.|...:.::.::..||...|    .:.|.....:|.:.:..:.|
Human    24 SSSQGRTGTGGSDVLQMQNSEHHGQSIKTQTDSISLEDVAVNFTLEEWALLDPGQRNIYRDVMRA 88

  Fly   284 T-----------PPSDAEPSPKQHRLGTQRKLSAPRAGTV--NGPSTTSGAATT--PELKYH--- 330
            |           ...|.|...|..    .|.|.:|....:  |......|.:|:  |:|..:
Human    89 TFKNLACIGEKWKDQDIEDEHKNQ----GRNLRSPMVEALCENKEDCPCGKSTSQIPDLNTNLET 149

  Fly   331 --------CDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHNCPE 387
                    |..|...|..:.||..|.|.    :...|.|||            |:.....|.|.|
Human   150 PTGLKPCDCSVCGEVFMHQVSLNRHMRS----HTEQKPNEC------------HEYGEKPHKCKE 198

  Fly   388 CGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQN 452
            ||.......::..| .:.|......:|..|.|.|..|.:.|:|:||||||.|:.|..|||:|...
Human   199 CGKTFTRSSSIRTH-ERIHTGEKPYECKECGKAFAFLFSFRNHIRIHTGETPYECKECGKAFRYL 262

  Fly   453 ANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRK 517
            ..||:|:..|:..|.:||:.|..:|:......:|.|||||:||:||:.|...|:....|..|::.
Human   263 TALRRHEKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQCGKAFSCPTYLRSHEKT 327

  Fly   518 HTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYIC 582
            ||||:|:.|..|...|.:.:.|:.|.:||||.:||.|..|.:.|.....|::|:|||.||:.|.|
Human   328 HTGEKPFVCRECGRAFFSHSSLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFGEKPYEC 392

  Fly   583 PVCNEEFKSMPEMRSHLAGHEQ 604
            ..|.:.|.|    .|:|..||:
Human   393 KQCGKAFNS----SSYLQLHER 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/22 (32%)
		COG5048	<357..570	CDD:227381	74/212 (35%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	3/16 (19%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	5/19 (26%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF490	NP_065765.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		5/28 (18%)
		KRAB	56..97	CDD:307490	7/40 (18%)
		C2H2 Zn finger	133..150	CDD:275368	4/16 (25%)
		C2H2 Zn finger	158..178	CDD:275368	7/23 (30%)
		COG5048	192..>505	CDD:227381	84/224 (38%)
		C2H2 Zn finger	196..216	CDD:275368	5/20 (25%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	8/19 (42%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	8/23 (35%)
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	476..496	CDD:275368
		C2H2 Zn finger	504..524	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910