DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zbtb33

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001072981.1	Gene:	Zbtb33 / 56805	MGIID:	1927290	Length:	671	Species:	Mus musculus

Alignment Length:	549	Identity:	106/549 - (19%)
Similarity:	194/549 - (35%)	Gaps:	157/549 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSIS 95
            |:....|.|:.:.|   |..|   .:||::.|      ..|:|..:..:.|..|| .|.::.::|
Mouse   208 DLPSNNTATQVQPN---PASV---AISEVTPC------ASNNSPPVTNITPTQLP-TPVNQATLS 259

  Fly    96 CPVATTDQAVQTTSWEPDRCTASV--QTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELP 158
            ....:.:..|.:.|   ...|.::  ...|..|.....::||
Mouse   260 QTQGSEELLVSSAS---THLTPNIILLNQAPLTAPPSASSSL----------------------- 298

  Fly   159 DEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVT 223
              |...::|:.:.||...        |..:.:..|:..|.|::|          :|::.:||:.:
Mouse   299 --PNHMSSSVNVLVQNQQ--------TPNSAVLTGNKAEEEEEI----------IDDDDDIISSS 343

  Fly   224 APQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSD 288
            .....:..|   |:.|.:|.|..|..||.     .:|.|:|.               :|..|||:
Mouse   344 PDSAVSNTS---LVPQADNSKSTTLDGSL-----TQKMQIPV---------------LPQEPPSN 385

  Fly   289 A------------EPSPK-QHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAV 340
            :            :|..: :|.:..|:.::...|..:.|.||
Mouse   386 SLKISDVITRNTNDPGLRSKHVMEGQKIITLDTATEIEGLST----------------------- 427

  Fly   341 EKSLMIHRRQKGC-INRNYKCNECEKVFVSPDHLAEHQASHGAHNCPECGIRCDSKEALSKH--- 401
                       || :..|...:..:.|....|.....:|..........|....:|....||
Mouse   428 -----------GCKVYANIGEDTYDIVIPVKDDPDGGEAKLDNELPKTSGSEPPNKRMKVKHDDH 481

  Fly   402 ---MVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHS 463
               :|.|....:   |.:|::.:..|::||.|..||:.||.:.|..|.|.|.......:|::.|:
Mouse   482 YELIVDGRVYYI---CIVCKRSYVCLTSLRRHFNIHSWEKKYQCRYCDKVFPLAEYRTKHEIHHT 543

  Fly   464 ETKSFKCELCPHSFVTKAELTSHART-HTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACD 527
            ..:.::|..|..||:....::||.:: |:.|...:.:  |.|.        |..|....|.||
Mouse   544 GERRYQCLTCGKSFINYQFMSSHIKSVHSQDPSGDSK--LYRL--------HPCKSLQIRQYA-- 596

  Fly   528 LCPMRFTALNVLKNHR---RTHTGERPYV 553
            ....:.:|:.|:|:..   :...|:.|.|
Mouse   597 YLSNKSSAMPVMKDDAVGYKVDAGKEPPV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	11/47 (23%)
		C2H2 Zn finger	331..354	CDD:275368	2/23 (9%)
		COG5048	<357..570	CDD:227381	47/207 (23%)
		C2H2 Zn finger	360..380	CDD:275368	3/19 (16%)
		C2H2 Zn finger	385..406	CDD:275370	5/26 (19%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..451	CDD:290200	11/23 (48%)
		C2H2 Zn finger	442..490	CDD:275368	12/48 (25%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	6/25 (24%)
		C2H2 Zn finger	498..518	CDD:275368	3/19 (16%)
		zf-H2C2_2	510..534	CDD:290200	5/23 (22%)
		C2H2 Zn finger	526..546	CDD:275368	3/22 (14%)
		zf-H2C2_2	539..563	CDD:290200	4/18 (22%)
		C2H2 Zn finger	554..574	CDD:275368	106/549 (19%)
		C2H2 Zn finger	582..602	CDD:275368
Zbtb33	NP_001072981.1	Self-association	1..136
		Interaction with NCOR1. /evidence=ECO:0000250	1..103
		BTB	22..116	CDD:279045
		BTB	33..116	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..161
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q86T24	298..571		69/375 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..365		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..474		3/22 (14%)
		Interaction with CTNND1	452..671		44/189 (23%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:15564377	469..478		1/8 (13%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		zf-H2C2_2	506..529	CDD:290200	10/22 (45%)
		Required for DNA-binding	512..637		31/126 (25%)
		C2H2 Zn finger	522..542	CDD:275368	5/19 (26%)
		zf-H2C2_2	537..557	CDD:290200	4/19 (21%)
		C2H2 Zn finger	550..571	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000