DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	449	Identity:	137/449 - (30%)
Similarity:	206/449 - (45%)	Gaps:	75/449 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 ELEQQIRE-CNLAIFEGVDNEAEIITVTAPQVTTRKSA------------AKLLTQQENDKHQTP 248
            |::.:..| ||..:||   ||:..|....|:..:.:.:            .:|......:.|...
Human   169 EIQSENGENCNQDMFE---NESRKIFSEMPEGESAQHSDGESDFERDAGIQRLQGHSPGEDHGEV 230

  Fly   249 VGSKEEAREL---------EKE-QVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRK 303
            |....|..:|         ||. :.||..|..||:..::..:...|       ..|.::.....|
Human   231 VSQDREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITHERTHT-------GEKYYKCDECGK 288

  Fly   304 LSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVF 367
            ..:..:......:|.:|     |..|.|..|...|:...:|:.|:| ..|  .:.::|.||.|.|
Human   289 SFSDGSNFSRHQTTHTG-----EKPYKCRDCGKSFSRSANLITHQRIHTG--EKPFQCAECGKSF 346

  Fly   368 VSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQG------------------HKRNL- 410
            ....:|..||.:|..   ::|||||....::.:|:.|  ||                  :..||
Human   347 SRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTH--QGIHTGEKPYECKECGESFSYNSNLI 409

  Fly   411 RNQ----------CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSET 465
            |:|          |..|.:.|:..|.|..|.|.||||||:.|:.|||||::::||..|:..|...
Human   410 RHQRIHTGEKPYKCTDCGQRFSQSSALITHRRTHTGEKPYQCSECGKSFSRSSNLATHRRTHMVE 474

  Fly   466 KSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCP 530
            |.:||.:|..||...:.|.:|...|||:||:||..|...|:.|.:|.||:|.||||:||.|..|.
Human   475 KPYKCGVCGKSFSQSSSLIAHQGMHTGEKPYECLTCGESFSWSSNLLKHQRIHTGEKPYKCSECG 539

  Fly   531 MRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEF 589
            ..|:..:.|..|:||||||:||.|..|.|:|::.....||||.|.|::.|.||.|.:.|
Human   540 KCFSQRSQLVVHQRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGF 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	90/244 (37%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	9/38 (24%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/8 (50%)
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011
		COG5048	251..631	CDD:227381	121/364 (33%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..303	CDD:275368	1/19 (5%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
		C2H2 Zn finger	367..387	CDD:275368	9/21 (43%)
		C2H2 Zn finger	395..415	CDD:275368	4/19 (21%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		C2H2 Zn finger	535..555	CDD:275368	6/19 (32%)
		C2H2 Zn finger	563..583	CDD:275368	8/19 (42%)
		C2H2 Zn finger	591..611	CDD:275368	4/8 (50%)
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910